A METAL-OXIDE, CHARACTERISTIC-LINE X-RAY IMAGING SOURCE

需要一种冠状动脉疾病筛查方法 不需要动脉导管的风险。数字减法 使用碘-K边缘减影的X线片受到低X射线的影响 强度和需要大量的碘浓度，排除了非 侵入性技术。需要更明亮的X射线源。我们 建议对金属氧化物进行评估，如 特征线X射线发射器。将有两种类型的设备 考虑：(1)大电流脉冲X射线枪，其金属-- 氧化物涂层薄靶窗口，(2)一种商业上可用的x- 具有改进型金属氧化物涂层旋转阳极的射线管。 这些源有望为K-EDGE产生有用的通量 二色性比约50倍 过滤的啤酒花-肺。我们还开发了一台计算机 碘-K边二色谱的模拟计算 特定X射线探测器成像所需的X射线通量 系统。这一模拟以及对 我们信号源的特征线X射线产生，表明 碘-钾边二色法是可能的。我们将在我们的 处置瓦里安联营公司的关键研究设施 斯坦福直线加速器中心和Adelphi Technology Inc. 这包括X射线探测设备、X射线源和 气相沉积设施。我们已经开发出一种数字X射线- 成像系统，也可用于这项工作。阿德尔菲 Technology Inc.拥有丰富的开发高级x- 用于医疗、科学和工业应用的射线源。一个 基于特征的医学诊断成像系统-- 这里正在开发的线源承诺了一种成本适中的非 动脉粥样硬化的侵入性筛查方法。

There is a need for a coronary-artery disease screening method not requiring the risk of an arterial catheter. Digital-subtraction radiographs using iodine-K-edge subtraction suffer from low x-ray intensities and require large iodine concentrations precluding non- invasive techniques. Brighter x-ray sources are needed. We propose to conduct an evaluation of metal oxides as characteristic-line x-ray emitters. Two types of devices will be considered: (1) A high-current pulsed x-ray gun with a metal- oxide-coated thin-target window, (2) A commercially available x- ray tube with a modified metal-oxide-coated rotating anode. These sources are expected to produce a useful flux for K-edge dichromography of approximately 50 times greater than that of filtered bremsstrah-lung. We have also developed a computer simulation of iodine-K-edge dichromography which determines the x-ray flux needed from imaging with a particular x-ray-detector system. This simulation together with an estimate of the characteristic-line x-ray production of our sources, indicate that iodine-K-edge dichromography is possible. We will have at our disposal critical research facilities of Varian Associates, the Stanford Linear Accelerator Center, and Adelphi Technology Inc. This includes x-ray detection equipment, x-ray sources, and vapor-deposition facilities. We have developed a digital x-ray- imaging system which is also available for this work. Adelphi Technology Inc. has extensive experience developing advanced x- ray sources for medical, scientific, and industrial applications. A medical diagnostic imaging system based upon the characteristic- line source being developed here promises a moderate-cost non- invasive method for screening atherosclerosis.