ELECTROCHEMICAL REACTOR TO DISINFECT REUSED DIALYZERS

该方案的最终目标是开发一种安全、可靠的 次氯酸盐电化学发生器，专门用于 重复使用的透析器的清洗和消毒。次氯酸盐有 被卫生保健机构广泛用于清洁 在甲醛消毒前重复使用透析器。一个 生产钠的电化学发生器系统 SET按需提供盐基次氯酸盐(NaCl)溶液 浓缩将提高安全性、重复性和 重复使用的透析器清洗工艺的可靠性。数量 所产生的次氯酸盐的数量将由 设置发电机的电流。这样做的具体目的是 第一阶段的建议是确定发展一个 流通式空气去极化电化学发电系统 1)在SET按需重复可靠地供应次氯酸盐 浓度和2)可见地清洁和去除残余血液 使用过的透析器中的成分。 实现这些目标的方法是1)制造一种空气 (02)去极化次氯酸钠发生器和导电体 用参数测试来定义效率、操作 特征/限制和与其他设备的接口要求 包括电气和解决方案控制组件和 2)评估用于去除残余血液成分的生成器 从用过的透析器中提取并恢复透析器的原始溶质 间距值。这项研究可能会导致 一种新型空气去极化次氯酸盐发生器，具体是 旨在以更低的功率水平清洁重复使用的透析器。 预计这一计划将导致 一种氧气去极化次氯酸钠发生器 在透析器重复使用的透析过程中的商业使用 才是最终目标。次氯酸盐发生器将允许 清洁步骤的自动化以确保最大程度的安全， 可重复性和有效性。这将增强 透析器重复使用的可靠性和质量保证。

The ultimate goal of the program is to develop a safe, reliable electrochemical hypochlorite generator specifically for use in the cleaning and disinfecting of reused dialyzers. Hypochlorites have been widely used by Health care facilities for the cleaning of reused dialyzers prior to sterilization with formaldehyde. An electrochemical generator system that produces sodium hypochlorite from salt (NaC1) solution on demand at set concentrations would increase safety, reproductibility and reliability of the reused dialyzer cleaning process. The quantity of hypochlorite generated would be accurately controlled by the set electric current of the generator. The specific aims of this Phase I proposal are to determine the feasibility of developing a flow-through air-depolarized electrochemical generator system to 1) reproducibly and reliably supply hypochlorite on demand at set concentrations and 2) viably clean and remove residual blood components from used dialyzers. The methodology for achieving these goals is to 1) fabricate an air (02) depolarized sodium hypochlorite generator and conduct parametric testing to define efficiency, operating characteristics/limitations and interface requirements to other subsystems including electric and solution control components and 2) evaluate the generator for removing residual blood components from a used dialyzer and restoring the dialyzer's original solute clearance value. The research could result in the development of a nove air-depolarized hypochlorite generator that is specifically designed to clean reused dialyzers at reduced power levels. It is expected that this program will lead to the development of an oxygen depolarized sodium hypochlorite generator for commerical use in the dialysis process where reuse of the dialyzer is the ultimate goal. The hypochlorite generator will allow automation of the cleaning step to insure maximum safety, reproducibility, and effectiveness. This would enhance the reliability and quality assurance for reuse of the dialyzers.