IMPLANTABLE STIMULATING MICROELECTRODES

随着神经刺激电极的发展， 注意力已经转向研究可能的不良副作用 随其使用。 这对于以下应用尤其如此： 需要在高电流密度下进行慢性刺激。 组织的风险 损害，这通常被认为是与有毒物种有关 在电极组织界面处电化学形成的， 对神经刺激的关注。 该计划的目标是 为了开发高表面积的“双层”型惰性电极， 用于神经元件的电刺激，从而有助于 用于治疗各种神经系统疾病的电气设备的发展 紊乱 在这个项目的第一阶段，我们准备并描述了 高表面积的金微电极， 1 mC/cm 2/相。 本文提出了进一步的研究，以提高 这些金电极的性能，并开发类似的电极， 其他兼容材料。 长期体外和体内研究 并对这些电极的性能进行评估。

As the development of neural stimulating electrodes is progressing, more attention has been directed towards studying possible adverse side effects attendant to their use. This is especially true for applications which require chronic stimulation at high current densities. The risk of tissue damage, which is generally believed to be associated with the toxic species formed electrochemically at the electrode tissue interface, has been a concern in neural stimulation. The objective of this proposed program is to develop high surface area "double layer" type inert electrodes suitable for the electrical stimulation of neural elements and thus to contribute to the development of electrical devices for treatment of various neurological disorders. In the Phase I of this program, we prepared and characterized high surface area gold microelectrodes which delivered a charge density of 1 mC/cm2/phase. Further studies are proposed here to improve the performance of these gold electrodes and to develop similar electrodes from other compatible materials. Both long term in vitro and in vivo studies will be carried out and performance of these electrodes will be assessed.