GLUCOSE SENSOR WITH IMPROVED STABILITY

植入式葡萄糖传感器的开发可以提供 更密切地控制糖尿病患者血糖水平的机会 现在有可能了。基于催化金属传感器的葡萄糖传感器工作原理 过去，我们的实验室一直在开发铂 几年来，在改善环境质量方面取得了很大进展 传感器的灵敏度、短期稳定性和选择性。 这项拟议的研究的目的是提高老年人的寿命 基于铂的电催化葡萄糖传感器。维护一个 在较长时间内保持恒定水平的传感器响应是 这是可取的，因为它避免了频繁重新校准的需要。第一阶段 在这个项目中的工作清楚地表明，专门制定的 聚合物结合的铂黑电极显示出一个数量级 在稳定性方面有所改善。 拟议的第二阶段计划旨在进一步优化电极 结构，开发适当的生物兼容外膜，并进行72 一小时的体内测试，以演示这项技术。

The development of an implantable glucose sensor could provide opportunities for a closer control of glucose levels in diabetes than is now possible. Glucose sensor work using catalytic metal sensor based upon platinum has been under development in our laboratories for the past several years, and considerable progress has been made in improving the sensitivity, short term stability, and selectivity of the sensor. The purpose of the proposed research is to improve the longevity of electro-catalytic glucose sensors based on platinum. Maintenance of a sensor response at a constant level over an extended period of time is desirable, since it avoids the need for frequent recalibration. Phase I work in this program has clearly demonstrated that specially formulated polymer bonded platinum black electrodes show an order of magnitude improvement in stability. The proposed Phase II program aims to further optimize the electrode structure, develop a proper biocompatible outer membrane, and conduct 72 hour in vivo tests to demonstrate the technology.