ELECTROCHEMICAL REACTOR TO DISINFECT REUSED DIALYZERS

该方案的最终目标是开发一种安全、可靠 专门用于清洁的电化学次氯酸盐发生器 以及对重复使用的透析器进行消毒。 次氯酸盐已被广泛应用于 由卫生保健机构在透析器重复使用之前进行清洁， 甲醛灭菌。 一种电化学发电机系统， 按需从盐（NaCl）溶液中生产次氯酸钠 浓度将提高安全性，可重复性和可靠性， 重复使用的透析器清洁过程。 生成的数量 次氯酸盐将被精确控制的电流的 生成器. 在该计划的第一阶段，我们成功地证明了 独特的电化学反应器，可按需生成次氯酸盐 而不产生氢气。 而且这 电化学产生的次氯酸钠，当冲洗通过 污染的透析器，显示可有效恢复尿素清除 和肌酸酐。 对于该计划的第二阶段，我们建议进一步改善这一独特的 精确控制次氯酸盐的电化学次氯酸盐发生器 浓度和pH值，并将其与商业再利用机器集成。 使用这种自动化的设置，我们建议表征运输 重复使用条件下高通量透析器的性能。

The ultimate goal of the program is to develop a safe, reliable electrochemical hypochlorite generator specifically for use in the cleaning and disinfecting of reused dialyzers. Hypochlorites have been widely used by health care facilities for the cleaning of reused dialyzers prior to sterilization with formaldehyde. An electrochemical generator system that produces sodium hypochlorite from salt (NaCl) solution on demand at set concentrations would increase safety, reproducibility and reliability of the reused dialyzer cleaning process. The quantity of generated hypochlorite would be accurately controlled by the electric current of the generator. In Phase I of this program, we successfully demonstrated that a unique electrochemical reactor that could generate hypochlorite on demand from NaCl without the generation of hydrogen. Furthermore, this electrochemically generated sodium hypochlorite, when flushed through a contaminated dialyzer, was shown to effectively restore clearance of urea and creatinine. For the Phase II of this program, we propose to further improve this unique electrochemical hypochlorite generator to precisely control hypochlorite concentration and pH, and integrate it with a commercial reuse machine. Using this automated setup, we propose to characterize the transport properties of high flux dialyzers under conditions of reuse.