GLUCOSE SENSORS WITH IMPROVED STABILITY

植入式葡萄糖传感器的开发可以提供 密切控制糖尿病患者血糖水平的机会 比现在可能的要多。葡萄糖传感器使用催化金属 基于铂的传感器目前正在我们的 实验室。到目前为止，在以下方面取得了相当大的进展 提高传感器的灵敏度和短期稳定性； 在存在时对葡萄糖的选择性的改善 共同反应物正在进行中。 拟议研究的目的是为了延长寿命。 以铂为基础的电催化葡萄糖传感器。 将传感器响应维持在恒定水平 延长一段时间是可取的，因为它避免了 频繁校准。在我们的实验室进行的初步研究 特制聚合物粘结铂黑电极 表现出更好的稳定性。拟议的工作试图开发 这一概念虽然严谨，但进一步证明了其可行性 测试和分析。

The development of an implantable glucose sensor could provide opportunities for a closer control of glucose levels in diabetes than is now possible. Glucose sensor work using a catalytic metal sensor based upon platinum is currently being performed in our laboratories. Considerable progress has been made so far in improving the sensitivity and short term stability of the sensor; improvements in selectivity towards glucose in the presence of co-reactants are under way. The purpose of the proposed research is to improve the longevity of electrocatalytic glucose sensors based on platinum. Maintenance of a sensor response at a constant level over an extended period of time is desirable, since it avoids the need for frequent calibration. Preliminary studies in our laboratories with specially formulated polymer-bonded platinum black electrodes show improved stability. The proposed work attempts to develop this concept further and prove its feasibility though rigorous testing and analysis.