METHOD OF SCREENING FOR OVULATORY DISORDERS

排卵障碍的筛查方法

• 批准号: 3499484
• 负责人: RANJIT S FERNANDO
• 金额: $ 4.93万
• 依托单位: ZETEK, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-05 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3499484
• 关键词: body temperature; female reproductive system disorder diagnosis; follicle stimulating hormone; human subject; ovary disorder; ovulation; ovulation detection /prediction; polycystic ovary syndrome; progesterone

Although many techniques are available for detecting the occurrence of ovulation, a simple screening technique that would detect either anovulation or ovulation disorders is not readily available. It is proposed to study the feasibility of extending the use of "CUE" technology, now used for predicting and confirming ovulation, to screening for and possibly identifying such disorders as anovulation, polycystic ovarian disease, luteal phase defect, and unruptured mature follicles. It is proposed that specific salivary reading (SR) and vaginal reading (VR) signals can be related to particular steps of selection, maturation and ovum release during the ovulatory process. SR and VR data, basal body temperature, ultrasound scans, assays for estradiol, luteinizing hormone, and progesterone will be evaluated from approximately 75 cycles of subjects with ovulation disorders. The method is expected to provide for early screening of infertility patients as well as women at risk for reproductive effects of exposure to hazardous substances in the workplace or the environment.

尽管有许多技术可用于检测 排卵的发生，一种简单的筛查技术， 检测不排卵或排卵障碍并不容易 available. 建议研究延长 使用“CUE”技术，现在用于预测和确认 排卵，筛查和可能识别这些疾病 如无排卵、多囊卵巢疾病、黄体功能不全、 和未破裂的成熟卵泡 建议具体 唾液阅读（SR）和阴道阅读（VR）信号可以 与选择、成熟和卵子的特定步骤有关 在排卵过程中释放。 SR和VR数据，基体 温度，超声扫描，雌二醇测定，促黄体生成 激素和孕酮将从大约 75个周期的排卵障碍受试者。 该方法 预计将为不孕症患者提供早期筛查， 以及有生殖风险的妇女， 工作场所或环境中的有害物质。