SALIVA AND CERVICAL MUCUS MONITOR TO DEFINE OVULATION

通过唾液和宫颈粘液监测来确定排卵

• 批准号: 3499247
• 负责人: RANJIT S FERNANDO
• 金额: $ 5万
• 依托单位: ZETEK, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-05-01 至 1985-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3499247
• 关键词: body temperature; cervix; clinical biomedical equipment; electrical impedance; electrolyte balance; electrolytes; family planning; female; fertility; genital secretion; luteinizing hormone; menstrual cycle; mucus; ovulation; ovulation detection /prediction; ovulation time; saliva

Preliminary studies performed by applicant indicate that the fertile period in women can be defined by monitoring electrical characteristics of saliva and cervical mucus. Previous investigators have shown that electrolyte constituents of these fluids change cyclically in relation to concentrations of reproductive hormones in women. More data are needed to validate the method. A probable physiological rationale for observed changes in salivary electrical resistance (SER) and vaginal electrical resistance (VER) and their relationship to the menstrual cycle has been generated and will be tested. In this study, fifty women will record daily measurements of SER and VER using a specially designed instrument. Basal Body Temperature (BBT) will be recorded, but will not be used to define the time of ovulation. Ovulation will be diagnosed by luteinizing hormone (LH) assay and, where appropriate, by ultrasound scan as well. Statistical evaluation of the correlation of the electrical measurements with ovulation will be performed. If successful, this research will result in a very useful tool for the management of infertility in the near future. Later, it is expected that the instrument will also be used to aid natural family planning.

申请人进行的初步研究表明，受孕期 女性可以通过监测唾液的电特性来确定 和宫颈粘液。 先前的研究人员表明电解质 这些流体的成分周期性变化 女性生殖激素的浓度。 需要更多数据来验证该方法。 可能的生理 观察到唾液电阻（SER）变化的基本原理和 阴道电阻（VER）及其与月经的关系 循环已生成并将进行测试。 在这项研究中，50 名女性将记录 SER 和 VER 的每日测量值 使用专门设计的仪器。 基础体温 (BBT) 将 被记录，但不会用于定义排卵时间。 排卵将通过黄体生成素 (LH) 测定来诊断，并且， 适当的，也可以通过超声波扫描。 统计评估 将进行电测量与排卵的相关性。 如果成功的话，这项研究将成为一个非常有用的工具 在不久的将来治疗不孕症。 稍后，预计 该仪器还将用于帮助自然计划生育。