SALIVA AND CERVICAL MUCAS MONITOR TO DEFINE OVULATION

通过唾液和宫颈粘膜监测来确定排卵

• 批准号: 3508111
• 负责人: RANJIT S FERNANDO
• 金额: $ 21.2万
• 依托单位: ZETEK, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-05-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508111
• 关键词: adrenocorticotropic hormone; aldosterone; atomic absorption spectrometry; body temperature; cervix; clinical biomedical equipment; clomiphene; computers; electrical impedance; electrolyte balance; electrolytes; estradiol; family planning; female; fertility; follicle stimulating hormone; genital secretion; luteinizing hormone; menstrual cycle; microelectrodes; mucus; ovulation; ovulation detection /prediction; ovulation time; patient monitoring device; potassium; radioimmunoassay; saliva; sodium; ultrasonography

Our aim is to examine usefulness of CUE readings for predicting and confirming ovulation. Methodological refinements will be used to develop it into an instrument that will be simple, inexpensive, and reliable. A detailed and expanded investigation of the concept will be done at the primary site (data on greater than 300 cycles) with independent verification on a smaller scale (150 cycles) at secondary sites. Besides luteinizing hormone assays for defining ovulation in most cycles ultrasound will be used un 70 cycles to examine the relation of CUE reading changes to ovulation. Since a thorough understanding of the physiological mechanisms involved is important, the relationships between ACTH, aldosterone, salivary electrolytes, and CUE salivary readings (SR) will be examined. As part of this trial, the contributions of estrogen through the renin-angiotensin system to changes in aldosterone, hence SR, will be defined. Usefulness of the method in induced ovulations was indicated in preliminary studies. This will be an important market segment, therefore, this application will be studied in 40 clomiphene and 20 "pergonal" induced cycles. Methodological development will be directed toward refining of sensor design, evaluating sodium-specific sensors, miniaturizing and prototyping the final microprocessor based instrument.

我们的目的是检验CUE读数对预测和预测的有用性