METHOD OF SCREENING FOR OVULATORY DISORDERS

排卵障碍的筛查方法

• 批准号: 3508182
• 负责人: RANJIT S FERNANDO
• 金额: $ 2.49万
• 依托单位: ZETEK, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-05 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508182
• 关键词: biomedical equipment resource; clinical biomedical equipment; computer assisted diagnosis; female reproductive system disorder diagnosis; human subject; ovary disorder; ovulation; ovulation detection /prediction; polycystic ovary syndrome

Although many techniques for detecting ovulation are now available, a simple-screening tool for detecting either anovulation or other ovulation disorders in not available. Preliminary findings in Phase I research has shown that specific atypic patterns in the ovulatory trends of salivary electrical resistance (SR) and vaginal electrical resistance (VR) are related to certain ovulatory disorders, i.e. Anovulation, Polycystic Ovarian Disease (PCOD), Luteinized Unruptured Follicle (LUF), and LUteal Phase Defect (LPD). In Phase II research, we propose to monitor SR and VR in groups of subjects representing each of the disorders mentioned and a well defined control group of subjects. Methods of screening for these disorders using SR and VR will be developed using these data, and incorporated in an instrument which will combine these capabilities with predicting the time of ovulation. The method is expected to provide for early screening of infertility patients as well as women at risk for reproductive effects of exposure to hazardous substances in the workplace or the environment.

虽然现在有许多检测排卵的技术， 用于检测不排卵或其他排卵的简单筛查工具 疾病不可用。 第一阶段研究的初步结果表明， 显示唾液中排卵趋势的特定模式 电阻（SR）和阴道电阻（VR）是 与某些排卵障碍有关，即无排卵、多囊 卵巢疾病（PCOD）、未破裂卵泡黄素化（LUF）和黄体 相位缺陷（LPD）。 在第二阶段的研究中，我们建议监测SR和VR 在代表所提及的每种疾病的受试者组中， 明确定义的受试者对照组。 筛选这些的方法 将使用这些数据开发使用SR和VR的疾病， 将这些能力结合在联合收割机中， 预测排卵的时间。 该方法预计将提供 对不孕症患者和有不孕风险的妇女进行早期筛查， 工作场所接触有害物质对生殖的影响 或环境。