SALIVA AND CERVICAL MUCAS MONITOR TO DEFINE OVULATION

通过唾液和宫颈粘膜监测来确定排卵

• 批准号: 3508112
• 负责人: RANJIT S FERNANDO
• 金额: $ 16.66万
• 依托单位: ZETEK, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-05-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508112
• 关键词: adrenocorticotropic hormone; aldosterone; atomic absorption spectrometry; body temperature; cervix; clinical biomedical equipment; clomiphene; computers; electrical impedance; electrolyte balance; electrolytes; estradiol; family planning; female; fertility; follicle stimulating hormone; genital secretion; luteinizing hormone; menstrual cycle; microelectrodes; mucus; ovulation; ovulation detection /prediction; ovulation time; patient monitoring device; potassium; radioimmunoassay; saliva; sodium; ultrasonography

Our aim is to examine usefulness of CUE readings for predicting and confirming ovulation. Methodological refinements will be used to develop it into an instrument that will be simple, inexpensive, and reliable. A detailed and expanded investigation of the concept will be done at the primary site (data on greater than 300 cycles) with independent verification on a smaller scale (150 cycles) at secondary sites. Besides luteinizing hormone assays for defining ovulation in most cycles ultrasound will be used un 70 cycles to examine the relation of CUE reading changes to ovulation. Since a thorough understanding of the physiological mechanisms involved is important, the relationships between ACTH, aldosterone, salivary electrolytes, and CUE salivary readings (SR) will be examined. As part of this trial, the contributions of estrogen through the renin-angiotensin system to changes in aldosterone, hence SR, will be defined. Usefulness of the method in induced ovulations was indicated in preliminary studies. This will be an important market segment, therefore, this application will be studied in 40 clomiphene and 20 "pergonal" induced cycles. Methodological development will be directed toward refining of sensor design, evaluating sodium-specific sensors, miniaturizing and prototyping the final microprocessor based instrument.

我们的目标是检验 CUE 读数对于预测和预测的有用性。 确认排卵。 方法论的改进将用于开发 它将成为一种简单、廉价且可靠的仪器。 对此概念进行详细和扩展的调查将在 主站点（超过 300 个周期的数据）具有独立的 在二级站点进行较小规模的验证（150 个周期）。 除了 黄体生成激素测定可确定大多数周期超声中的排卵 将使用 70 个周期来检查 CUE 读数变化与 排卵。 由于彻底了解所涉及的生理机制是 重要的是ACTH、醛固酮、唾液之间的关系 将检查电解质和 CUE 唾液读数 (SR)。 作为一部分 在该试验中，雌激素通过肾素-血管紧张素的贡献 将定义醛固酮变化的系统，因此 SR。 初步表明该方法在诱导排卵中的有用性 研究。 这将是一个重要的细分市场，因此， 将在 40 种克罗米芬和 20 种“pergonal”诱导中研究应用 循环。 方法学的发展将致力于传感器的改进 设计、评估钠专用传感器、小型化和原型制作 最终基于微处理器的仪器。

项目成果

Natural family planning: suitability of the CUE method for defining the time of ovulation.

自然计划生育：CUE 方法确定排卵时间的适用性。

• DOI: 10.1016/s0010-7824(97)00007-3
• 发表时间: 1997
• 期刊: Contraception
• 影响因子: 2.9
• 作者: Moreno,JE;Khan-Dawood,FS;Goldzieher,JW
• 通讯作者: Goldzieher,JW