FIBER OPTIC SENSOR FOR MEASURING LEAD IN BLOOD

用于测量血液中铅的光纤传感器

• 批准号: 3496765
• 负责人: Judith L. Erb
• 金额: $ 5万
• 依托单位: IA, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496765
• 关键词: biomedical equipment development; biosensor device; blood chemistry; fiber optics; ionophores; lead; monitoring device

Innovation Associates proposes to develop and validate a fiber optic sensor for measuring lead in blood which can measure 1-100 micro g/dL concentrations of lead in blood using an innovative Lead Ion Selective Fiber Optode (LISFO) technology. The proposed sensor will require a blood volume less than 200 micro L and will be capable of repeated sample analysis every 3 minutes. It will operate with an accuracy and a precision of 5-10% or better when measuring 10 micro g/dL lead concentrations. This will make the instrument suitable for lead screening programs under the new CDC guideline of 10 micro g/d. Use of fiber optic technology will provide a rugged, compact portable instrument and will allow low cost screenings of blood lead concentrations to be performed. Sample preparation will be automated so that minimally trained operators can achieve reliable results with minimal opportunity for sample contamination. The electronic output from the device will be designed to interface with a PC so that an entered patient ID will be printed together with the test results. The sensor will utilize elements which have been individually validated in other systems, but which have heretofore not been combined.

Innovation Associates建议开发和验证光纤 可测量1-100微克/分升的血铅测量传感器 使用创新的铅离子选择性测定仪检测血液中的铅浓度 光纤光电二极管（LISFO）技术。 拟议的传感器将需要血液 体积小于200 μ L，能够重复取样 每3分钟分析一次。 它将以一种精确和 测量10 μ g/dL铅时，精度为5-10%或更高 浓度的 这将使仪器适合铅筛选 根据新的CDC指南10微克/天。 使用光纤 技术将提供一种坚固、紧凑的便携式仪器， 允许进行低成本的血铅浓度筛查。 样品制备将自动化，以便最低限度培训的操作员 能够以最少的采样机会获得可靠的结果 污染. 器械的电子输出将被设计为 与PC连接，以便将输入的患者ID打印在一起 测试结果 传感器将利用已被 在其他系统中单独验证，但迄今为止还没有 被组合。