BIODEGRADABLE VASCULAR GRAFTS

可生物降解的血管移植物

• 批准号: 3502399
• 负责人: IH-HOUNG LOH
• 金额: $ 5万
• 依托单位: AST PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502399
• 关键词: angiogenesis; antithrombogenic surface; biomaterial development /preparation; biotransformation; cell adhesion; polymers; surface property; tissue /cell culture; vascular endothelium; wound healing

The use of biodegradable polymers for vascular reconstruction has two major advantages: the elimination of chronic foreign body reaction and the regeneration of arterial tissues including a nonthrombogenic pseudointima layer. However, it is well-known that the healing of human vascular tissues is very slow thus the risk of using biodegradable vascular grafts in human beings is the premature degradation of biodegradable vascular grafts. In this proposal, we are suggesting an novel method to accelerate the regeneration of arterial tissue, particularly the formation of a thrombus-free pseudointima lining of the graft. Phase I objective is to determine the feasibility to chemically modify surface characteristics of synthetic biodegradable polymers to control their adhesion characteristics for endothelial cells. Controlling the surface character of these polymers could a) lead to a better understanding of the interactions between cells and foreign materials during wound healing and b) significantly improve the biological and chemical properties of biodegradable polymers for use as new materials for the reconstruction of injured, diseased or aged human tissues and organs. The most important impact of this proposed research is to provide the required knowledge basis for rendering synthetic biodegradable polymers to have the surface property that could selectively attract desirable cells for their subsequent attachment, growth and cellular functions.

使用生物可降解聚合物进行血管重建有两个 主要优点：消除慢性异物反应， 动脉组织的再生，包括非血栓形成的 假内膜层 然而，众所周知，人类的愈合 血管组织是非常缓慢的，因此使用可生物降解的 人类的血管移植物是过早降解的 可生物降解的血管移植物。 在这份提案中，我们建议 加速动脉组织再生的新方法， 特别是形成无血栓的假内膜衬里， 移植物 第一阶段的目标是确定化学改性的可行性 合成生物可降解聚合物的表面特性， 它们对内皮细胞的粘附特性。 控制 这些聚合物的表面特性可以a）导致更好的 了解细胞和异物之间的相互作用 和B）显著改善生物学和 用作新材料的生物可降解聚合物的化学性能 用于重建受伤、患病或老化的人体组织， 机关 这项拟议研究的最重要影响是提供 合成生物可降解聚合物所需的知识基础 具有可以选择性地吸引期望的 细胞用于其随后的附着、生长和细胞功能。