PEO STAR MOLECULES AS THROMBORESISTANT SURFACES

PEO 星形分子作为抗血栓表面

• 批准号: 3502259
• 负责人: IH-HOUNG LOH
• 金额: $ 5万
• 依托单位: AST PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502259
• 关键词: antithrombin III; antithrombogenic surface; biomaterial development /preparation; blood cell count; blood coagulation; cell adhesion; complement pathway; covalent bond; hemostasis; heparin; human tissue; ligands; oxides; plasma; platelet activation; platelet aggregation; polyethylenes; prothrombin time; thrombin; thromboplastin; thrombosis

Blood in contact with an artificial surface can lead to short term platelet deposition, activation and thrombosis, and to coagulation via activation of the intrinsic clotting system. Long term effects may result in complement activation. This proposal centers on utilizing a new class of PEO molecules, in the form of stars, to accomplish two things: (1) Completely cover the underlying support material so that it cannot be accessed by any of the precursors of thrombosis, coagulation or complement activation. This should produce a "non-thrombogenic" surface, but not an "anti-thrombogenic" surface. (2) To provide at the same time molecular "leashes" (i.e., PEO chains), at the ends of which are covalently attached a molecular such as heparin which will carry out a specific interaction with blood. This is an example of a (potentially) antithrombogenic surface.

血液与人造表面接触可导致短期血小板