NOVEL BIOELECTRODE FOR NEUROSCIENCE APPLICATIONS

用于神经科学应用的新型生物电极

• 批准号: 3504386
• 负责人: IH-HOUNG LOH
• 金额: $ 3.33万
• 依托单位: AST PRODUCTS, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3504386
• 关键词: clinical biomedical equipment; drug delivery systems; electrodes; implant; neural transmission; neurosciences

All novel bioelectrode will be fabricated from conducting polymers. In a proper condition, this bioelectrode can be electrochemically reduced with resulting incorporation of neurotransmitters, such as acetyl choline, gamma-aminobutyrate, dopamine, or glutamate, into the polymer matrix of the bioelectrode. The neurotransmitter can be remained entrapped within the conducting polymer matrix when the bioelectrode is kept at a proper potential. When the bioelectrode is stimulated by an electric pulse, the entrapped neurotransmitter can be released from the polymer matrix. The novel electrode described here is prototype for a device which could be used to deliver small amounts of biomedically interesting materials to specific locations at specific times.

所有新型生物电极都将由导电聚合物制成。中 在适当的条件下，这种生物电极可以电化学还原， 导致神经递质，如乙酰胆碱， γ-氨基丁酸盐、多巴胺或谷氨酸盐的聚合物基质中 生物电极。神经递质可以被困在 当生物电极保持在适当的温度时， 潜力当生物电极被电脉冲刺激时， 包埋的神经递质可以从聚合物基质中释放出来。的 这里描述的新型电极是一种装置的原型， 用于输送少量生物医学材料， 在特定时间特定地点