NOVEL BIOELECTRODE FOR NEUROSCIENCE APPLICATIONS

拟议研究的主要目标是开发新的方法 用于输送少量的生物医学材料， 作为神经递质或激素，用于神经科学应用。 在第一阶段的工作中成功地证明， 大量的多巴胺可以被加载，然后从一个 导电聚合物体系 第二阶段的发展将继续 第一阶段工作的成功，并侧重于a）对 控释机制，B）实际器械概念开发，c） 动物体内生物电极装置表征，d）测量 生物电极材料反应的其它方面 无法在体外获得，如生物相容性，和e）关键 商业化问题。 这种导电聚合物生物电极不仅可用于 神经递质研究，但也用于其他应用，如 控制药物释放，证明药物化学品以 响应于电信号的适当时刻。 小说 这里描述的输送系统是一种装置的原型， 用于输送受控量的生物医学上感兴趣的 在特定时间将材料运送到特定地点。

The primary objective of the proposed research is to develop new methods for delivering small amounts of biomedically interesting materials, such as neurotransmitters or hormones, for use in neuroscience applications. It was successfully demonstrated during the Phase I work that small quantities of dopamine could be loaded and then released from a conducting polymer system. Phase II development will continue the success of Phase I work and focus on a) fundamental understanding of controlled release mechanisms, b) actual device concepts development, c) in vivo bioelectrode device characterization in animals, d) measurement of other aspects of the reaction of the bioelectrode materials which cannot be obtained in vitro, such as biocompatibility, and e) critical commercialization issues. This conducting polymer bioelectrode will be useful not only for neurotransmitter studies, but also for other applications, such as controlled drug release, demonstrating release of drug chemicals at an appropriate moment in response to an electric signal. The novel delivery system described here is a prototype for a device which could be used to deliver controlled amounts of biomedically interesting materials to specific locations at specific times.