IBAD COATINGS FOR ADVANCED SPIRAL CUFF ELECTRODES

适用于高级螺旋套电极的 IBAD 涂层

• 批准号: 3504683
• 负责人: PIRAN SIOSHANSI
• 金额: $ 5万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3504683
• 关键词: adhesions; bioengineering /biomedical engineering; biomedical automation; biomedical equipment development; clinical biomedical equipment; electrodes; method development; molecular film; nervous system prosthesis; neuromuscular stimulator; particle beam; platinum; printing; semiconduction; silicone rubber; titanium

Simple cuff electrodes, because they are easily fabricated, easily implanted, and highly reliable, have been the workhorse electrodes for most of the clinically applied neural prostheses in spite of their "off- on" characteristics. While electrodes that permit graduated neural activation would yield better control, they cannot now be fabricated in the form of a safe and practical cuff. This limitation has recently been overcome by investigators at Case Western Reserve University (CWRU), who have demonstrated selective activation of nerves in animals with a self- wrapping spiral cuff electrode of patented design. The CWRU electrodes are now fabricated one-at-a-time in a laborious, time consuming series of manual operations whose output is small and whose product in unreliable; to fully realize the benefits of CWRU's innovation, an improved, mass-producible versions must be developed. Such an electrode is the subject of Spire's proposal. Ion beam assisted deposition (IBAD) will be used to place a thin, highly adherent, conducting film on silicone rubber and standard semiconductor processing techniques (photolithography) used to define electrodes in it. This approach will allow reliable, repeatable production of the spiral cuff electrode design and make possible designs with smaller features and more stimulating surfaces. Prototype cuffs will be manufactured in Phase I. In Phase II, we will further refine the fabrication process and test the electrodes in extensive, long-term animal studies.

简单的袖套电极，因为它们很容易制造，很容易 植入的、高度可靠的电极一直是 大多数临床应用的神经假体，尽管它们是“关闭的-- 特征。而允许分级神经的电极 激活将产生更好的控制，它们现在不能在 安全实用的袖口形式。这一限制最近一直是 凯斯西储大学(CWRU)的调查人员克服了这一点，世界卫生组织 在患有自闭症的动物身上表现出选择性的神经激活 专利设计的缠绕螺旋袖套电极。 CWRU电极现在是在一次一个费力的时间内制造出来的 耗费一系列人工操作，其产量小，且 产品不可靠；充分实现CWRU的好处 为了创新，必须开发改进的、可批量生产的版本。 这样的电极是斯皮尔提议的主题。 离子束辅助沉积(IBAD)将被用来放置薄的、高度 硅橡胶和标准半导体上的粘附性导电膜 用于在其中定义电极的处理技术(光刻)。 这种方法将允许可靠、可重复地生产螺旋 袖口电极设计，并使设计成为可能，具有更小的特征和 更刺激的表面。原型袖口将分阶段生产 一、在第二阶段，我们将进一步完善制造工艺和测试 在广泛的、长期的动物研究中使用电极。