DEVELOPMENT OF POROUS COMPOSITE BIOMATERIALS

该提案的具体目的是证明以下方案的可行性： 生产具有弹性性能的复合植入材料 与聚二甲基硅氧烷基本相似，生物学特性 与高表面能陶瓷基本相似，例如钙 羟基磷灰石。 该复合材料由陶瓷颗粒组成 多孔聚合物基质。 创新的纤维增强技术将 用于抵消聚合物基质的性能。 维持 陶瓷的生物功能，一种保存其陶瓷的技术 将利用暴露的表面积。 原料及影响 研究工艺参数，对样品进行彻底研究 使用体外技术进行表征。 在多孔复合材料领域 对于人体植入，这将提供一种柔软、有弹性的材料 丰富的高能表面积；从而允许应力转移和组织 附件以增强固定。 主要的商业应用将是 低应力承受种植体，用于颌面重建或 牙科修复应用。 如果这个项目产生令人鼓舞的成果 结果、免费赠款资金和内部财务将得到利用 继续进行最佳变体的临床前体内测试 技术。

The specific aim of this proposal will be to demonstrate the feasibility of producing a composite implant material with elastic properties substantially similar to polydimethylsiloxane, and biological properties substantially similar to high surface energy ceramics, such as calcium hydroxyapatite. The composite will consist of ceramic particles held in a porous polymeric matrix. An innovative fiber reinforcement technique will be utilized to negate the properties of the polymer matrix. To maintain the biological functionality of the ceramic, a technique of preserving its exposed surface area will be utilized. The effects of raw materials and processing parameters will be studied, and samples will be thoroughly characterized using in vitro techniques. In the field of porous composites for human implantation, this will provide a soft, flexible material with an abundant high-energy surface area; thus allowing stress transfer and tissue attachment to enhance fixation. The primary commercial application will be low-stress bearing implants, for use in maxillofacial reconstruction or dental restorative applications. If this project yields encouraging results, complimentary grant funds and internal finances will be utilized to proceed with preclinical in vivo testing of the best variations of the technology.