AN IMPROVED WOUND DRESSING SUITABLE FOR BURN TREATMENT

该项目的目标是提供改进的伤口敷料 基于聚合物膜，能够改变其 湿气渗透性以适应伤口的特定条件。 该膜将是透明的，细菌和液态水无法渗透， 并具有自粘特性，可以轻松地将其从 伤口表面。 新开发的聚合物组合物将被修改 提供自动调节透气性或“智能” 行为。 互穿聚合物网络（“IPN”） 聚二甲基硅氧烷（“PDMS”）和聚四氟乙烯（“PTFE”） 目前用作伤口敷料。 所得产品将具有 增加湿气渗透性和液体储存能力 存在严重渗出的伤口。 同样的穿衣会减少 当渗出物减少时其蒸气渗透性，从而避免伤口 干燥。 该第一阶段项目将从原型生产开始， 继续进行体外和体内测试，并得出结论 第二阶段的结果和建议的解释。

The objective of this project is to provide an improved wound dressing based on a polymeric membrane which has the capability of changing its moisture vapor permeability to suit the particular conditions of the wound. The membrane will be transparent, impermeable to bacteria and liquid water, and possess self-cling properties which allow it to be easily removed from the wound surface. A newly developed polymer composition will be modified as to provide the self-adjusting vapor permeability or "intelligent" behavior. An interpenetrating polymer network ("IPN") of polydimethylsiloxane ("PDMS") and polytetrafluoroethylene ("PTFE") is currently used as a wound dressing. The resulting product will have increased moisture vapor permeability and fluid storage capacity when in the presence of heavily exuding wounds. The same dressing will decrease its vapor permeability when exudate decreases, thus avoiding wound desiccation. This Phase I project will begin with prototype production, continue with in vitro and in vivo testing, and conclude with interpretation of results and recommendations for Phase II.