THERMOPLASTIC SILOXANE-URETHANE COPOLYMER DEVELOPMENT

该项目将测试热塑性塑料的生物稳定性 聚氨酯（TPU）可以通过替换全部或部分聚氨酯（TPU）来改进。 含遥爪聚二甲基硅氧烷（PSX）的聚醚软段 低聚物在合成过程中。 这一做法是基于报告的 通过以下方法改善溶剂浇铸聚氨酯的体内稳定性 反应性PSX在氨基甲酸酯基聚合物中的混合或接枝 和已知的PSX体内稳定性。 在I期中，研究了几种不同制剂的皮下体内稳定性。 聚氨酯将被确定。 来自PSX的芳香族TPU， 聚环氧乙烷和聚环氧乙烷以及几种PSX/聚醚 预聚氨基甲酸酯膜在预聚后的特征在于： 能够检测分子量的本体和表面分析方法 减少和变化的表面化学和形态与 降解过程。 I期试验的阳性结果将用于II期试验， 生物医学PSX-TPU系列的开发和商业化。 这些材料将适用于溶剂浇铸、挤出和热处理。 注塑成型。 它们将结合联合收割机的抗生物降解性和 PSX理想的表面性能，具有加工方便和宽 常规TPU中可用的一系列整体性能。

This project would test the hypothesis that biostability of thermoplastic polyurethanes (TPU) can be improved by replacing all or part of the polyether soft segment with telechelic polydimethylsiloxane (PSX) oligomer during synthesis. This approach is based on the reported improvement in-vivo stability of solvent-cast polyurethanes through the admixture or grafting of reactive PSX into/onto urethane vased polymers and the known in-vivo stability of PSX. In Phase I the subcutaneous in-vivo stability of several different polyurethane will be determined. Aromatic TPUs from PSX, polytetramethyleneoxide and polyethyleneoxide and several PSX/polyether terpolymer polyurethane films will be characterized after explantation by bulk and surface analytical methods capable of detecting molecular weight reduction and changes in surface chemistry and morphology associated with the degradation process. Positive phase I results will be utilized in Phase II to complete the development and commercialization of a family of biomedical PSX-TPUs. These materials will be suitable for solvent casting, extrusion and injection molding. They will combine the biodegradation resistance and desirable surface properties of PSX, with the processing ease and wide range of bulk properties available in conventional TPUs.