POLYMERS WITH STEP-WISE VARIABLE SURFACE COMPOSITION

描述（来自申请人的摘要的逐字）： 生物材料科学到目前正在开发的设备将受益于 具有逐步可变表面的良好表征的聚合物的可用性 混合物.表面化学本体组成的控制在以下方面具有实用性： 组织工程，在制造传统的医疗设备和在新的 聚合物的纳米技术应用。在阶段中，我们证实，虽然利率 较慢，聚合物共混物的平衡表面张力/组成是 定量类似于液体溶剂中的常规表面活性剂。能源 最小化驱动表面平衡，这取决于 接口，例如，空气vs.血液第二阶段包括编制三个系列 具有不同表面组成的聚合物共混物，每一种都具有不同的 表面改性端基：硅酮、氟碳化合物、聚环氧乙烷。 每个系列将通过几种表面敏感方法进行表征 包括和频产生光谱、XPS、AFM和表面 张力/润湿性。每个特征化系列将接受电池测试 短期体外生物学试验，包括（竞争性）蛋白质 吸附和补体激活。睾丸的假设是， 生物反应将随表面化学性质单调变化， 表面化学通过真正的表面敏感方法确定， 聚合物表面重排的动力学知识， 将空气平衡的表面浸入含水液体中。 拟议商业应用：不可用

DESCRIPTION (Verbatim from the Applicant's Abstract): The application of biomaterials science to devices now in development would benefit from the availability of well-characterized polymers with step wise variable surface composition. Control of surface chemistry bulk composition has utility in tissue engineering, in fabrication of conventional medial devices and in new nanotechnology application of polymers. In Phase we confirmed that, while rates are slower, equilibrium surface tension/composition of polymer blends is quantitatively similar to conventional surfactants in liquid Solvents. Energy minimization drives surface equilibration, which depends on the nature of the interface, e.g., air vs. blood. Phase II involves preparation of three series of polymer blends with varying surface composition, each with a different surface modifying end group: silicone, fluorocarbon, polyethyleneoxide. Each series will be characterized by several surface-sensitive methods including Sum Frequency Generation Spectroscopy, XPS, AFM and surface tension/wettability. Each characterized series will be subjected to a battery of short-term in vitro biological tests including (competitive) protein adsorption and complement activation. The hypothesis to be testes is that biological response will vary monotonically with surface chemistry when the surface chemistry is determined by truly surface-sensitive methods and knowledge of the kinetics of polymer surface rearrangement following upon immersion of air-equilibrated surfaces into aqueous fluids. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE