课题基金 / 基金详情

CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR

CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR
卡拉胶稳定胶体金生物传感器
批准号:
3507884
负责人:
JOHN P O'DALY
金额:
$25.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-07-15 至 1991-12-31

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项目成果

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中文摘要
翻译
酶固定在胶体金和涂上卡拉胶提供
英文摘要
Enzymes immobilized on colloidal gold and coated with carrageenan offer an important new route to amperometric biosensor electrodes. Our objective is to fabricate these electrodes by deposition of colloidal gold containing the enzyme onto the surface of a conducting material such as carbon, followed by the attachment of a thin layer of carrageenan. Bioelectrodes can be used to produce second generation amperometric biosensors that are well suited to satisfy major needs in human health- care. Reliable amperometric biosensors for substances such as cholesterol will find extensive applications in the prevention, diagnosis and treatment of diseases. Major problems with current first generation commercial biosensor designs include instability, slow response, and interferences caused by the lack of direct, efficient coupling between the bioactive component and the transducer. Our successful technology based on the use of carrageenan based support materials and colloidal gold immobilized enzymes overcomes limitations of current designs and offers a viable route to new amperometric biosensors. Enzyme Technology Research Group, Ins., will do research and development on overall design, fabrication, and biocatalytic properties of the electrodes. A Duke University research team will assist in the evaluation of the eletrochemical properties of the electrodes.
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ELECTRO-IMMUNOSENSOR TO DETECT COCAINE & THC METABOLITE
  • 批准号:
    2120308
  • 项目类别:
  • 资助金额:
    $25.0万
  • 财政年份:
    1994
  • 负责人:
    JOHN P O'DALY
  • 依托单位:
ELECTRO-IMMUNOSENSOR TO DETECT COCAINE & THC METABOLITE
  • 批准号:
    2120310
  • 项目类别:
  • 资助金额:
    $24.25万
  • 财政年份:
    1994
  • 负责人:
    JOHN P O'DALY
  • 依托单位:
ELECTRO-IMMUNOSENSOR TO DETECT COCAINE AND THC METABOLIT
  • 批准号:
    2120307
  • 项目类别:
  • 资助金额:
    $5.0万
  • 财政年份:
    1992
  • 负责人:
    JOHN P O'DALY
  • 依托单位:
IMMOBILIZED OXIDOREDUCTASE ENZYMES IN ORGANIC SYNTHESIS
  • 批准号:
    3508047
  • 项目类别:
  • 资助金额:
    $24.1万
  • 财政年份:
    1992
  • 负责人:
    JOHN P O'DALY
  • 依托单位:
海外基金