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Exploitation of genomic technologies for sustainable intensification of dairy goats

利用基因组技术实现奶山羊可持续集约化

基本信息

批准号：
BB/M027570/1
负责人：
Joanne Conington
金额：
$ 33.39万
依托单位：
Scotland's Rural College
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FM027570%2F1
关键词：
Exploitation genomic technologies sustainable intensification

项目摘要

This project addresses key challenges facing the sustainable intensification of dairy goat milk production by using new genetic and genomic technologies to improve the efficiency of milk production and continuity of supply. A key constraint is the inability of dairy goats to naturally breed out of season, thereby affecting year-round supply of milk. This project therefore will identify sires with daughters that readily breed out of season and to generate genomic predictions of merit for this trait. The exploitation of such ability by the wider commercial goat industry in the UK and abroad will be enabled via genomic predictions for this and a range of other key traits via the development in this project of a low density (LD), lower cost customised single nucleotide polymorphism (SNP) array for UK goats. This will facilitate the imputation from LD to the higher density SNP arrays and allow a greater proportion of the outer herd nucleus to be genotyped, thereby creating greater uptake and impact to the wider UK goat population and beyond. The project will ensure that the balance of breeding objectives for dairy goats is sustainable in the long-term, by including routine collection of conformation scoring and mastitis records as proxy indicators of animal health and longevity into the genomic predictions, thereby helping to translate this and previous TSB-funded research into practice

该项目通过使用新的遗传和基因组技术来提高牛奶生产效率和供应连续性，解决可持续集约化奶山羊奶生产面临的关键挑战。一个关键的限制是奶山羊无法在淡季自然繁殖，从而影响全年的牛奶供应。因此，该项目将识别容易反季节繁殖的父本和父本，并生成该性状优点的基因组预测。在英国和国外更广泛的商业山羊产业利用这种能力将通过基因组预测这一点和一系列其他关键性状，通过在该项目中开发低密度（LD），低成本定制的单核苷酸多态性（SNP）阵列英国山羊。这将有助于从LD到更高密度SNP阵列的插补，并允许更大比例的外部畜群核心进行基因分型，从而对更广泛的英国山羊群体及其他群体产生更大的吸收和影响。该项目将确保奶山羊育种目标的平衡在长期内是可持续的，方法是将常规收集的形态评分和乳腺炎记录作为动物健康和寿命的替代指标纳入基因组预测，从而帮助将这项和以前TSB资助的研究转化为实践。