ELECTROSPRAY IONIZATION MASS SPECTROMETRY SYSTEM

最先进的三重四极杆质谱仪， 电离源将用于化学学院 科学质谱实验室，以支持研究的 化学，生物化学， 和生命科学学院 该系统将用于研究 微量的高分子量生物大分子。 电喷雾电离系统的主要用户将是J。克罗南， 小的，R. B。让尼斯河I. Gumport，A. Jonas，K.L. Rinehart，S. G.斯利加， 和K. S. Suslick在他们的翻译后修饰的研究中， ACP来自E.大肠杆菌;呼吸电子传递中的膜酶 序列特异性蛋白质-DNA相互作用的识别; 血浆高密度脂蛋白结构与功能 抗生素、缩氨酸及有关化合物化学 细胞色素P-450催化机理;血红素类似物的合成 蛋白质;其他用户将是A。R. Crofts，A. L. DeVries，S.京， 和G. W. Ordal在结构/功能关系研究中的应用 光合酶的转换;抗冻蛋白在极性中的作用 鱼类.分子量和遗传顺序的测定 基因工程蛋白质和DNA分子; 细菌趋化性

A state-of-the-art triple quadrupole mass spectrometer with an electrospray ionization source will be employed for use in the School of Chemical Sciences Mass Spectrometry Laboratory to support the research of the faculty, postdoctorates, and graduate students in Chemistry, Biochemistry, and the School of Life Sciences. The system will be employed for the study of trace amounts of biological macromolecules of high molecular weight. Major users of the electrospray ionization system will be J. E. Cronan, Jr., R. B. Gennis, R. I. Gumport, A. Jonas, K.L. Rinehart, S. G. Sligar, and K. S. Suslick in their studies of post-translational modifications of ACP from E. coli; membrane enzymes in respiratory electron transport reactions; recognition of sequence-specific protein-DNA interactions; structure and function of plasma high density lipoproteins; structure and chemistry of antibiotics, peptides, and related compounds; chemical mechanism of cytochrome P-450 catalysis; synthetic analogs of heme proteins; Additional users will be A. R. Crofts, A. L. DeVries, S. Kyin, and G. W. Ordal in studies of structure/function relationships in photosynthetic enzyme conversions; the role of antifreeze proteins in polar fishes; the determination of molecular weights and sequences of genetically engineered proteins and DNA molecules; the study of sensory transduction by bacterial chemotaxis.