ELECTROSPRAY IONIZATION MASS SPECTROMETRY SYSTEM

一种最先进的电喷雾三重四极质谱计 电离源将在化学学院使用 科学质谱学实验室支持研究 化学、生物化学专业的教师、博士后和研究生， 和生命科学学院。该系统将被用于研究 微量的高分子生物大分子。 电喷雾电离系统的主要用户将是J.E.Cronan， 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 和K.S.Suslick在他们对翻译后修饰的研究中 来自大肠杆菌的ACP；呼吸电子传递中的膜酶 反应；识别特定序列的蛋白质-DNA相互作用； 血浆高密度脂蛋白的结构和功能 抗生素、多肽及相关化合物的化学；化学 细胞色素P-450的催化机理；合成的血红素类似物 蛋白质；其他用户将是A.R.克罗夫茨、A.L.DeVries、S.Kyin、 和G.W.Ordal在《关于结构/功能关系的研究》中 光合酶转化；抗冻蛋白在极地的作用 鱼.分子量和遗传序列的测定 工程蛋白质和DNA分子；感官传导的研究 细菌趋化性。

A state-of-the-art triple quadrupole mass spectrometer with an electrospray ionization source will be employed for use in the School of Chemical Sciences Mass Spectrometry Laboratory to support the research of the faculty, postdoctorates, and graduate students in Chemistry, Biochemistry, and the School of Life Sciences. The system will be employed for the study of trace amounts of biological macromolecules of high molecular weight. Major users of the electrospray ionization system will be J. E. Cronan, Jr., R. B. Gennis, R. I. Gumport, A. Jonas, K.L. Rinehart, S. G. Sligar, and K. S. Suslick in their studies of post-translational modifications of ACP from E. coli; membrane enzymes in respiratory electron transport reactions; recognition of sequence-specific protein-DNA interactions; structure and function of plasma high density lipoproteins; structure and chemistry of antibiotics, peptides, and related compounds; chemical mechanism of cytochrome P-450 catalysis; synthetic analogs of heme proteins; Additional users will be A. R. Crofts, A. L. DeVries, S. Kyin, and G. W. Ordal in studies of structure/function relationships in photosynthetic enzyme conversions; the role of antifreeze proteins in polar fishes; the determination of molecular weights and sequences of genetically engineered proteins and DNA molecules; the study of sensory transduction by bacterial chemotaxis.