GAS & LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY SYSTEM

气体

• 批准号: 3520135
• 负责人: JIRI JONAS
• 金额: $ 40万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-06 至 1990-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520135
• 关键词: biomedical equipment purchase; gas chromatography mass spectrometry

A modern mass spectrometer with coupled gas chromatography and liquid chromatography inlets and chemical ionization capability will be employed for routine use in the School of Chemical Sciences Mass Spectrometry Laboratory to support the research of faculty, postdoctorates, and graduate students in Chemistry and Biochemistry. This instrument will replace a 16-year-old spectrometer. Major users of the GC/LC/CIMS system will be P. Beak, R. M. Coates, S. E. Denmark, J. A. Katzenellenbogen, K. L. Rinehart, G. B. Schuster, K. S. Suslick, S. C. Zimmermann, and S. G. Sligar in their studies of terpene, sterol, and antibiotic biosynthesis and synthesis; metalloenzymes, products formed by them, and their synthetic analogs; DNA bis-intercalators; fluorine-labeled steroids and substituted estrogens; structures of antibiotics, marine natural products and insect neuropeptides; photochemical products from organoboron compounds; novel synthetic intermediates (organometallic and chiral reagents, deuterium labeled). Additional users will be N. J. Leonard, E. Oldfield, D. N. Hendrickson, W. G. Klemperer, T. B. Rauchfuss, C. A. Broka, I. C. Gunsalus, L. P. Hager, and R. S. Wolfe, and they will employ the GC/LC/CIMS system in studies of nucleic acid analogues, cytochrome cleavage peptides, methanogen coenzymes, metalloproteins, halogenating enzymes, phospholipids, glycolipids, glycosphingolipids, transition metal sulfide clusters, low temperature ceramics, and synthetic intermediates for marine natural products and terpenes.

带有耦合气相色谱法和的现代质谱仪和 液相色谱入口和化学电离能力 将在化学科学学院常规使用 质谱实验室支持教师的研究， 博士后，化学和研究生 生物化学。 该乐器将取代16岁 光谱仪。 GC/LC/CIMS系统的主要用户将是P. Beak，R。M. Coates， S. E. Denmark，J。A。Katzenellenbogen，K。L。Rinehart，G。B。 Schuster，K。S。Suslick，S。C。Zimmermann和S. G. Sligar 他们对萜烯，固醇和抗生素生物合成的研究以及 合成;金属酶，它们形成的产品及其 合成类似物； DNA双互换器；氟标记的类固醇 并取代雌激素；抗生素的结构，海洋 天然产物和昆虫神经肽；光化学产品 来自有机体化合物；新型合成中间体 （有机金属和手性试剂，标记氘）。 其他用户将是N. J. Leonard，E。Oldfield，D。N. Hendrickson，W。G。Klemperer，T。B。Rauchfuss，C。A。Broka Gunsalus，L。P。Hager和R. S. Wolfe，他们将雇用 GC/LC/CIMS系统在核酸类似物的研究中，细胞色素 切割肽，甲烷原辅酶，金属蛋白，金属蛋白， 卤代酶，磷脂，糖脂，， 糖磷脂，过渡金属硫化物簇，低 温度陶瓷和海洋的合成中间体 天然产品和萜烯。

项目成果

Rh(2)(II)-catalyzed synthesis of carbazoles from biaryl azides.

• DOI: 10.1021/jo9002536
• 发表时间: 2009-04-17
• 期刊: The Journal of organic chemistry
• 作者: Stokes BJ;Jovanović B;Dong H;Richert KJ;Riell RD;Driver TG
• 通讯作者: Driver TG

Anticancer (hexacarbonyldicobalt)propargyl aryl ethers: synthesis, antiproliferative activity, apoptosis induction, and effect on cellular oxidative stress.

• DOI: 10.1016/j.jinorgbio.2012.10.014
• 发表时间: 2013-02
• 期刊: Journal of inorganic biochemistry
• 影响因子: 3.9
• 作者: Sydonie D Schimler;D. Hall;Stefan L. Debbert

Synthetic tuning of electronic and photophysical properties of 2-aryl-1,3-benzothiaphospholes.

2-芳基-1,3-苯并硫杂磷的电子和光物理性质的综合调节。

• DOI: 10.1021/jo400947u
• 发表时间: 2013
• 期刊: The Journal of organic chemistry
• 作者: Worch,JoshuaC;Chirdon,DanielleN;Maurer,AndrewB;Qiu,Yunyan;Geib,StevenJ;Bernhard,Stefan;Noonan,KevinJT
• 通讯作者: Noonan,KevinJT

Examination of the mechanism of Rh(2)(II)-catalyzed carbazole formation using intramolecular competition experiments.

• DOI: 10.1021/jo901224k
• 发表时间: 2009-09-04
• 期刊: The Journal of organic chemistry
• 作者: Stokes BJ;Richert KJ;Driver TG
• 通讯作者: Driver TG

Tocopheryl acetates from the pupal exocrine secretion of the squash beetle, Epilachna borealis (Coccinellidae).

醋酸生育酚来自南瓜甲虫 Epilachna borealis（瓢虫科）的蛹外分泌物。

• DOI: 10.1007/bf01969741
• 发表时间: 1996
• 期刊: Experientia
• 作者: Attygalle,AB;Smedley,SR;Eisner,T;Meinwald,J
• 通讯作者: Meinwald,J