GAS & LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY SYSTEM

气体

• 批准号: 3520135
• 负责人: JIRI JONAS
• 金额: $ 40万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-06 至 1990-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520135
• 关键词: biomedical equipment purchase; gas chromatography mass spectrometry

A modern mass spectrometer with coupled gas chromatography and liquid chromatography inlets and chemical ionization capability will be employed for routine use in the School of Chemical Sciences Mass Spectrometry Laboratory to support the research of faculty, postdoctorates, and graduate students in Chemistry and Biochemistry. This instrument will replace a 16-year-old spectrometer. Major users of the GC/LC/CIMS system will be P. Beak, R. M. Coates, S. E. Denmark, J. A. Katzenellenbogen, K. L. Rinehart, G. B. Schuster, K. S. Suslick, S. C. Zimmermann, and S. G. Sligar in their studies of terpene, sterol, and antibiotic biosynthesis and synthesis; metalloenzymes, products formed by them, and their synthetic analogs; DNA bis-intercalators; fluorine-labeled steroids and substituted estrogens; structures of antibiotics, marine natural products and insect neuropeptides; photochemical products from organoboron compounds; novel synthetic intermediates (organometallic and chiral reagents, deuterium labeled). Additional users will be N. J. Leonard, E. Oldfield, D. N. Hendrickson, W. G. Klemperer, T. B. Rauchfuss, C. A. Broka, I. C. Gunsalus, L. P. Hager, and R. S. Wolfe, and they will employ the GC/LC/CIMS system in studies of nucleic acid analogues, cytochrome cleavage peptides, methanogen coenzymes, metalloproteins, halogenating enzymes, phospholipids, glycolipids, glycosphingolipids, transition metal sulfide clusters, low temperature ceramics, and synthetic intermediates for marine natural products and terpenes.

具有耦合气相色谱和分析功能的现代质谱仪 液相色谱入口和化学电离能力 将在化学学院日常使用 质谱实验室支持教师的研究， 化学和化学领域的博士后和研究生 生物化学。 该乐器将取代 16 岁的 光谱仪。 GC/LC/CIMS 系统的主要用户是 P. Beak、R. M. Coates、 S. E. 丹麦，J. A. Katzenellenbogen，K. L. Rinehart，G. B. 舒斯特 (Schuster)、K. S. Suslick、S. C. Zimmermann 和 S. G. Sligar 他们对萜烯、甾醇和抗生素生物合成的研究 合成;金属酶、由它们形成的产物及其 合成类似物； DNA双嵌入剂；氟标记类固醇 和替代雌激素；抗生素的结构，海洋 天然产物和昆虫神经肽；光化学产品 来自有机硼化合物；新型合成中间体 （有机金属和手性试剂，氘标记）。 其他用户包括 N. J. Leonard、E. Oldfield、D. N. 亨德里克森、W. G. 克伦佩勒、T. B. 劳赫福斯、C. A. 布罗卡、I. C. Gunsalus、L. P. Hager 和 R. S. Wolfe，他们将采用 GC/LC/CIMS 系统在核酸类似物、细胞色素研究中的应用 裂解肽、产甲烷菌辅酶、金属蛋白、 卤化酶、磷脂、糖脂、 鞘糖脂、过渡金属硫化物簇、低 高温陶瓷、海洋合成中间体 天然产物和萜烯。

项目成果

Rh(2)(II)-catalyzed synthesis of carbazoles from biaryl azides.

• DOI: 10.1021/jo9002536
• 发表时间: 2009-04-17
• 期刊: The Journal of organic chemistry
• 作者: Stokes BJ;Jovanović B;Dong H;Richert KJ;Riell RD;Driver TG
• 通讯作者: Driver TG

Anticancer (hexacarbonyldicobalt)propargyl aryl ethers: synthesis, antiproliferative activity, apoptosis induction, and effect on cellular oxidative stress.

• DOI: 10.1016/j.jinorgbio.2012.10.014
• 发表时间: 2013-02
• 期刊: Journal of inorganic biochemistry
• 影响因子: 3.9
• 作者: Sydonie D Schimler;D. Hall;Stefan L. Debbert

Examination of the mechanism of Rh(2)(II)-catalyzed carbazole formation using intramolecular competition experiments.

• DOI: 10.1021/jo901224k
• 发表时间: 2009-09-04
• 期刊: The Journal of organic chemistry
• 作者: Stokes BJ;Richert KJ;Driver TG
• 通讯作者: Driver TG

Synthetic tuning of electronic and photophysical properties of 2-aryl-1,3-benzothiaphospholes.

2-芳基-1,3-苯并硫杂磷的电子和光物理性质的综合调节。

• DOI: 10.1021/jo400947u
• 发表时间: 2013
• 期刊: The Journal of organic chemistry
• 作者: Worch,JoshuaC;Chirdon,DanielleN;Maurer,AndrewB;Qiu,Yunyan;Geib,StevenJ;Bernhard,Stefan;Noonan,KevinJT
• 通讯作者: Noonan,KevinJT

Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat.

野豌豆种子中的豌豆素、普鲁那辛和β-氰基丙氨酸是大鼠尿硫氰酸盐的来源。

• DOI: 10.1021/jf010343w
• 发表时间: 2001
• 期刊: Journal of agricultural and food chemistry
• 影响因子: 6.1
• 作者: Ressler,C;Tatake,JG
• 通讯作者: Tatake,JG