NIMH-CRB PSYCHOBIOLOGY DEPRESSION PROGRAM-BIO

先前的研究强烈表明，情感障碍患者 有一种或多种神经生物学功能异常 系统。在NIMH临床研究分会召开的一次会议上， 回顾了这些发现，并对一些阻碍因素进行了分析 走向更全面、更全面地了解联合国系统的运作 躁狂症或抑郁症患者的神经生物学系统 已确认身份。因此，NIMH赞助开发了一种 多研究中心，以合作的方式研究 情感障碍的心理生物学。在这个协作项目中， 已经进行了几年，主要目标是测试 广泛的假说，涉及神经化学在病因学和 情感障碍的维持。为了实现这一点， 重点是：(A)评估若干机构的运作情况 同一患者体内不同类型的生物系统 在治疗期间；(B)获得大量患者并进行比较 受试者；和(C)跨中心使用标准化诊断 分类和行为方法论。在之前的授权期内 数据已经合并，数据分析已经开始。初步 结果已经报告，一系列研究正在进行中。这个 这项建议的具体目标是继续测试 早些时候以及现在，与行为和行为相关的假设 生理病理学，以及治疗反应性，可能 确定抑郁症患者的特征，并将他们与健康人区分开来 研究对象。

Prior research strongly suggests that patients with affective disorders have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, NIMH, these findings were reviewed and some of the factors which were impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, the NIMH sponsored the development of a mutiresearch center, collaborative approach to the study of the psychobiology of affective disorders. In this collaborative program, underway for several years, the major objectives have been the testing of a wide range of hypotheses which implicate neurochemistry in the etiology and maintenance of the affective disorders. In order to accomplish this, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient both before and during treatment; (b) obtaining a large number of patients and comparison subject; and (c) the use across centers of standardized diagnostic categories and behavioral methodologies. During the preceding grant period the data have been consolidated and data analysis has begun. Preliminary results have been reported and a range of studies are in progress. The specific aim of this proposal is the continuation of the testing of earlier, as well as current, hypotheses related to the behavioral and physiological pathology, as well as to treatment responsivity which may characterize depressed patients and differentiate them from healthy subjects.