Core Equipment to underpin the National Crystallography Service 2020-

回应这一呼吁的战略是提供一个平衡的方法，以确保具有前瞻性的组成部分的基本更换设备，这是通过将“投资以节省”和“支撑多用户设备”这两个方面结合起来来实现的。国家晶体学服务中心（NCS）是一个世界知名的机构，拥有庞大的用户群，是第一个成立的国家研究机构（1981年）。该NRF非常适合最大化核心设备投资的利益和受益者，是一个先进的设施，具有全国性的影响力，并采用既定的协调方法来维护和扩大其用户群。NRF模式提供了准入机制、专家支持、监测、治理和可持续的运营模式，以确保这项投资将充分发挥其最大潜力。通过参与NCS的正式治理和审查程序，确定了主要设备项目，即一种新的测角仪。因此，它是一个真正的关键设备组件，处于危险之中，它的更换将使NCS的性能和吞吐量保持在一个持续的高水平。继续以高标准交付NCS核心业务将通过引入高倍显微镜来支持，该显微镜将提供新的功能以及更多的冗余和更高的吞吐量。另外两项设备，一个智能测角仪头和一个低温恒温器，将支持NCS的技术开发方面。前者将提供一种全新的方法来减轻样品衰减，并将与仪器制造商一起开发。后者将完成40万英镑的设备贷款，以支持基于水晶海绵技术的全新能力。这是一个与默克和理学公司合作的联合开发/影响项目，这将使我们能够获得纳米级材料或不易结晶物质的结构数据。其目的是使其成为NCS服务提供的一个新组成部分，并与已经建立的战略合作伙伴关系一起，它将在学术界和工业界发展并显著影响新的晶体学用户社区。NCS在社区中的独特地位和影响力将通过其核心业务，先进的方法和技术开发工作使这项设备投资的受益者人数最大化。庞大的既定用户群延伸到博士生和ECR-所有这些人都有机会获得该设备提供的技能培训。 总之，由于有能力继续维持高水平的服务提供，NCS还可以通过与主要行业和仪器制造商建立伙伴关系，通过完善的路线和明确的影响途径，为这项投资增加重要价值。

The strategy in answering this call is to provide a balanced approach to secure essential replacement equipment with a forward-looking component and this is achieved by bringing together the two strands of 'invest to save' and 'underpinning multi-user equipment'. Coupled with established routes to supporting and enabling ECRs and doctoral students, the National Crystallography Service (NCS) is able to touch on all the Core Equipment call objectives.The NCS is a world-renowned facility with a large user base and was the first National Research Facility to be established (1981). This NRF is ideally suited to maximising the benefits and beneficiaries of a Core Equipment investment, being an advanced facility with a national reach and an established, coordinated approach to maintaining and expanding its user base. The NRF model provides the access mechanisms, expert support, monitoring, governance and sustainable operating model to ensure that this investment will be fully realised to its maximum potential.The main equipment item, a new goniometer, has been identified through involving the formal governance and review procedures of the NCS. It is therefore a truly key equipment component that is at risk and its replacement will enable a continued high level of performance and throughput of the NCS. The continued delivery of NCS core business at a high standard will be supported by the introduction of a high-powered microscope which will provide new capability as well as more redundancy and higher throughput. The other two items of equipment, an Intelligent Goniometer Head and a cryostat, will support the technique development aspect of the NCS. The former will provide an entirely new approach to mitigating against sample decay and would be developed with the instrument manufacturer. The latter will complete a £400k equipment loan to underpin an entirely new capability based around the crystal sponge technique. This endeavour is a joint development/impact project partnering with Merck and Rigaku companies, which would enable acquisition of structural data on nanolitres of material or substances that don't readily crystallise. The aim is for this to become a new component of the NCS service provision and with strategic partnerships already in place, it will develop and significantly impact new crystallography user communities in academia and industry. The unique position and reach of the NCS in the community will enable maximisation of the number of beneficiaries of this equipment investment through its core business, advanced methods and technique development work. The large established user base reaches through to PhD students and ECRs - all of whom would have opportunity for skills training provided with this equipment. In conclusion, with the ability to continue to sustain the high level of service provision, the NCS can also add significant value to this investment through well-established routes and clearly identified pathways to impact via partnerships with key industry and instrument manufacturers.