MISSION (Mid- Infrared Silicon Photonic Sensors for Healthcare and Environmental Monitoring)

MISSION（用于医疗保健和环境监测的中红外硅光子传感器）

基本信息

批准号：
EP/V047663/1
负责人：
Graham Reed
金额：
$ 733.66万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FV047663%2F1
关键词：
MISSION Mid Infrared Silicon Photonic

项目摘要

Silicon Photonics, the technology of electronic-photonic circuits on silicon chips, is transforming communications technology, particularly data centre communications, and bringing photonics to mass markets, utilising technology in the wavelength range 1.2 micrometres - 1.6 micrometres. Our vision is to extend the technical capability of Silicon Photonics to Mid -Infrared (MIR) wavelengths (3-15 micrometres), to bring the benefits of low cost manufacturing, technology miniaturisation and integration to a plethora of new applications, transforming the daily lives of mass populations. To do this we propose to develop low-cost, high performance, silicon photonics chip-scale sensors operating in the MIR wavelength region. This will change the way that healthcare, and environmental monitoring are managed. The main appeal of the MIR is that it contains strong absorption fingerprints for multiple molecules and substances that enable sensitive and specific detection (e.g. CO2, CH4, H2S, alcohols, proteins, lipids, explosives etc.) and therefore MIR sensors can address challenges in healthcare (e.g. cancer, poisoning, infections), and environmental monitoring (trace gas analysis, climate induced changes, water pollution), as well as other applications such as industrial process control (emission of greenhouse gases), security (detection of explosives and drugs at airports and train stations), or food quality (oils, fruit storage), to name but a few. However, MIR devices are currently realised in bulk optics and integrated MIR photonics is in its infancy, and many MIR components and circuits have either not yet been developed or their performance is inferior to their visible/near-IR counterparts. Research leaders from the Universities of Southampton, Sheffield and York, the University Hospital Southampton and the National Oceanography Centre will utilise their world leading expertise in photonics, electronics, sensing and packaging to unleash the full potential of integrated MIR photonics. We will realise low cost, mass manufacturable devices and circuits for biomedical and environmental sensing, and subsequently improve performance by on-chip integration with sources, detectors, microfluidic channels, and readout circuits and build demonstrators to highlight the versatility of the technology in important application areas. We will initially focus on the following applications, which have been chosen by consulting end users of the technology (the NHS and our industrial partners): 1) Therapeutic drug monitoring (e.g. vancomycin, rifampicin and phenytoin); 2) Liquid biopsy (rapid cancer diagnostics from blood samples); 3) Ocean monitoring (CO2, CH4, N2O detection).

硅光子学是硅芯片上电子光电电路的技术，正在转换通信技术，尤其是数据中心通信，并将光子学带到大众市场，利用波长范围1.2微米-1.6微米。我们的愿景是将硅光子学的技术能力扩展到中红外（MIR）波长（3-15微米），以将低成本制造，技术小型化和整合的好处带到新的应用中，从而改变了大众人口的日常生活。为此，我们建议开发在miR波长区域运行的低成本，高性能，硅光子片尺度传感器。这将改变医疗保健和环境监测的方式。 miR的主要吸引力是它包含可实现敏感和特定检测的多种分子和物质的强吸收指纹（例如CO2，CO2，CH4，H2S，H2S，酒精，蛋白质，蛋白质，脂质，炸药等），因此MIR传感器可以解决医疗中的挑战（例如，癌症，污染），污染了（例如，污染），污染了（例如，污染），污染了环境，环境，环境，环境，环境，环境，环境，环境，环境，污染了环境，环境，环境，环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，污染了环境，并可以解决。以及其他应用，例如工业过程控制（温室气体的排放），安全性（在机场和火车站的爆炸物和毒品）或食品质量（油，水果储存）等应用。但是，目前在批量光学元件中实现了miR设备，并且综合的miR光子学尚处于起步阶段，许多miR组件和电路尚未开发，或者它们的性能不如它们的可见/近IIR对应物。来自南安普敦，谢菲尔德和约克大学，南安普敦大学和国家海洋学中心的研究领导者将利用其世界领先的光子学，电子，感应和包装方面的领先专业知识，以释放综合mir光子学的全部潜力。我们将实现低成本，可制造的质量制造设备和环境感应的电路，然后通过与来源，探测器，微流体渠道以及读取电路和构建示威者的芯片整合来提高性能，以突出重要应用领域的技术多功能性。我们最初将专注于以下应用程序，这些应用程序是由该技术的最终用户（NHS和我们的工业伙伴）选择的：1）治疗药物监测（例如Vancomycin，Rifampicin和shemytoin）； 2）液体活检（血液样本的快速癌症诊断）； 3）海洋监测（CO2，CH4，N2O检测）。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Integrated Switching Circuit for Low-Noise Self-Referenced Mid-Infrared Absorption Sensing Using Silicon Waveguides

DOI：
10.1109/jphot.2021.3121331
发表时间：
2021-12
期刊：
IEEE Photonics Journal
影响因子：
2.4
作者：
Y. Qi;Zhexuan Zheng;M. Banakar;Yangbo Wu;Anushka S. Gangnaik;D. Rowe;V. Mittal;J. Butement;J. Wilkinson;G. Mashanovich;M. Nedeljkovic
通讯作者：
Y. Qi;Zhexuan Zheng;M. Banakar;Yangbo Wu;Anushka S. Gangnaik;D. Rowe;V. Mittal;J. Butement;J. Wilkinson;G. Mashanovich;M. Nedeljkovic

Group IV mid-infrared photonics for communications and sensing

用于通信和传感的第四组中红外光子学

DOI：
10.1117/12.2616700
发表时间：
2022
期刊：
影响因子：
0
作者：
Mashanovich G
通讯作者：
Mashanovich G

Improving tuberculosis treatment using mid-infrared spectroscopy for bedside therapeutic drug monitoring

使用中红外光谱进行床边治疗药物监测改善结核病治疗

DOI：
10.1117/12.2649135
发表时间：
2023
期刊：
影响因子：
0
作者：
Rowe D
通讯作者：
Rowe D

Prediction of Neonatal Respiratory Distress Biomarker Concentration by Application of Machine Learning to Mid-Infrared Spectra.

DOI：
10.3390/s22051744
发表时间：
2022-02-23
期刊：
Sensors (Basel, Switzerland)
影响因子：
0
作者：
Ahmed W;Veluthandath AV;Rowe DJ;Madsen J;Clark HW;Postle AD;Wilkinson JS;Murugan GS
通讯作者：
Murugan GS

Ge-on-Si waveguide device for self-referenced fingerprint region absorption spectroscopy

用于自参考指纹区域吸收光谱的硅基硅波导装置