THYROID NODULARITY FOLLOWING EXPOSURE-DIAGNOSTIC I-131

暴露后甲状腺结节诊断 I-131

• 批准号: 3627068
• 负责人: LARS ERIK HOLM
• 金额: $ 16万
• 依托单位: KAROLINSKA INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-31 至 1993-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3627068
• 关键词: Scandinavian country; biomarker; cancer risk; evaluation /testing; human subject; hyperthyroidism; in situ hybridization; mammography; neoplasm /cancer epidemiology; neoplasm /cancer radionuclide diagnosis; radiation dosage; radionuclide imaging /scanning; thyroid neoplasm; thyroiditis

The purpose of this project is to evaluate the risk of thyroid nodularity among patients exposed to low-dose radioactive iodine (I-131). Physical examinations of the head and neck will be performed on two Swedish populations: 1000 women with a history of exposure to diagnostic doses of I-131, and 250 general population comparisons undergoing mammographic screening. Risk will be evaluated over a range of doses of diagnostic I- 131, and risk for the low dose women will be compared with that for the general population comparison group. The exposed population will be selected from previously identified patient cohorts and the mammography screenees will be chosen from women participating in national screening programs. The rates of detected thyroid diseases known to be related to low-dose radiation (cancer, adenomas, nodules) and those not so related (e.g., hyperthyroidism, thyroiditis, hypothyroidism) will be compared in the study groups and by dose, and other biological markers of exposure (e.g., fluorescent in situ hybridization translocation analysis) will be evaluated to learn more about biological markers as potential dosimeters.

本项目的目的是评估甲状腺结节的风险 暴露于低剂量放射性碘（I-131）的患者。 物理 将对两名瑞典人进行头部和颈部检查， 人群：1000名有诊断剂量暴露史的妇女 I-131和250例接受乳腺X线摄影的普通人群比较 筛选 将在诊断性碘的剂量范围内评估风险- 131，低剂量女性的风险将与 普通人群对照组。 暴露人群将从先前确定的患者中选择 队列和乳房X线摄影筛查将从女性中选择 参与国家筛查项目。 检出率 已知与低剂量辐射有关的甲状腺疾病（癌症， 腺瘤，结节）和那些不相关的（例如，甲状腺机能亢进， 甲状腺炎，甲状腺功能减退症）将在研究组中进行比较， 剂量，以及其他暴露的生物标记（例如，荧光原位 杂交易位分析）将进行评估，以了解更多关于 生物标记物作为潜在的剂量计。