Digital Health: Innovative engineering technologies to improve the understanding and management of fatigue

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Fatigue is considered as a "final common pathway": a vague clinical symptom that can result from many different diseases and mechanisms. Our limited understanding of fatigue stems, in part, from its subjective and fluctuating nature and its complex interplay of parameters associated with "tiredness" such as sleep, exercise, and mood. This project will investigate sensory technologies to objectively, accurately and unobtrusively measure fatiguability, as an indicator of fatigue. These measurements will be correlated to sensed data (activity levels, sleep, heart rate, and others) and individuals' self-reports. Granular details will be obtained about patterns in the human fatigue experience. The results will reveal whether there could be distinct, clinically relevant fatigue phenotypes. We will also use longitudinal research (studying participants closely over a several week period). To date, longitudinal fatigue research been limited by statistical analysis methods (such as multilevel modelling) which are unable to detect subtle or complex relationships between fatigue and related life-style factors over time. We will use artificial intelligence algorithms to help analyse and classify these correlations within the sensed data, self-reports and qualitative data.