DISTRIBUTION OF MOUSE MODELS FOR NEURAL TUBE DEFECTS

动物模型是鉴定肿瘤的重要实验准备 人类健康问题的病因学。 动物模型的鉴定 适用于表征潜在的发育生物学 出生缺陷发生的机制对婴儿特别重要。 NICHD的使命。 因为中枢神经系统的畸形 是人类最具破坏性的发育缺陷，NICHD专注于 关于神经管缺陷的两种动物模型的开发。 两个鼠标 神经管缺陷（NTD），TCu/tct和卷曲尾模型， 根据合同N01-HD-6 - 2925和N01-HD-6 - 2926开发。 本合同的具体目标是维护和分发 在NICHD支持下开发的两种突变小鼠品系。 的 承包商是为了保持育种股票的基因定义 在健康条件下，用20个菌株，ct/ct，TCu/TCu，tct/tct， 变异动物的巴黎随时可供分配。 的 动物将以每对二十一元的价格分发给调查人员。 的 承包商将保留所有动物的完整繁殖记录， 胚胎将被冷冻，以确保不会丢失。 在 为了确保科学界了解这项服务， 承包商将制定一项计划，以宣传这些 突变模型，将其列入杰克逊实验室目录， 在期刊上刊登广告，并在科学期刊上展示数据， 会议.

Animal models are important experimental preparations for identifying the etiology of health problems in humans. The identification of animal models suitable for characterizing the underlying developmental biological mechanisms by which birth defects occur is especially important to the missions of the NICHD. Since malformations of the central nervous system are the most devastating developmental defects of man, the NICHD has focuse on the development of two animal models for neural tube defects. Two mouse models for neural tube defects (NTD), the TCu/tct and the curly tail were developed under contracts N01-HD-6-2925 and N01-HD-6-2926. The specific objective of this contract is to maintain and distribute the two mutant strains of mice which were developed under NICHD support. The contractor is to maintain breeding stocks of the genetically defined strains, ct/ct, TCu/TCu, tct/tct, in a healthy condition with 20 breeding paris of mutant animals available for distribution at all times. The animals are to be distributed to investigators at $21 per pair. The contractor will maintain complete breeding records on all the animals, and embryos will be frozen in order to ensure that stocks are not lost. In order to ensure that the scientific community is aware of this service, the contractor will institute a program to publicize the availability of these mutant models by advertizing them in the Jackson Laboratory catalogue, by placing advertisements in journals and by presenting data at scientific meetings.