FUNCTIONAL BRAIN MAPPING OF COCAINE ACTION

这是一个研究基本人类的计划项目的申请 可卡因作用的神经科学。我们提出了一个连贯的和高度的 基于功能磁共振的综合研究小组 人体受试者和动物模型的成像(FMRI)。基础科学 这项研究的目标是(1)了解人类体内的电路 可卡因引起的欣快感、戒断焦虑症和可卡因- 条件性渴求，(2)研究区域大脑的差异 非依赖者和依赖者中可卡因的激活。按顺序 为了充分利用功能磁共振成像的优势， 计划涉及该工具的技术开发，优化其 对假想的皮质和皮质下结构进行成像的能力 在人脑奖赏回路中扮演关键角色。使用动物模型 因为他们是解释生物学所必需的 人类功能磁共振成像数据的意义及其与有效分子的关联 可卡因诱导的神经激活模型。

This is an application for a Program Project to study the basic human neuroscience of cocaine action. We propose a coherent and highly integrated group of studies based on functional magnetic resonance imaging (fMRI) of human subjects and animal models. The basic scientific goals of the study are to (1) understand the circuitry in humans that underlies cocaine induced euphoria, withdrawal dysphoria and cocaine- conditioned craving, (2) to investigate differences in regional brain activation by cocaine in nondependent versus dependent users. In order to take full advantage of the strengths of fMRI, one aspect of the program involves technical development of this tool, optimizing its ability to image cortical and subcortical structures hypothesized to play key roles in the human brain reward circuitry. Animal models are used in the program because they are necessary to interpret the biological significance of human fMRI data and to relate it well validated molecular models of cocaine-induced neural activation.