FUNCTIONAL BRAIN MAPPING OF COCAINE ACTION

这是一个项目的应用程序，研究基本的人类 可卡因作用的神经科学 我们提出了一个连贯和高度 基于功能磁共振的综合研究组 人类受试者和动物模型的功能磁共振成像（fMRI）。 基础科学 这项研究的目的是（1）了解人类的电路， 可卡因诱发的欣快症，戒断焦虑症和可卡因- 条件性渴求，（2）探讨区域脑差异 可卡因在非依赖性与依赖性使用者中的激活。 为了 为了充分利用功能磁共振成像的优势， 该计划涉及该工具的技术开发，优化其 能够成像皮质和皮质下结构假设发挥 在人类大脑奖励回路中的关键作用。 使用动物模型 因为它们是解释生物学 人类功能磁共振成像数据重要性及其相关的有效分子 可卡因诱导的神经激活模型。

This is an application for a Program Project to study the basic human neuroscience of cocaine action. We propose a coherent and highly integrated group of studies based on functional magnetic resonance imaging (fMRI) of human subjects and animal models. The basic scientific goals of the study are to (1) understand the circuitry in humans that underlies cocaine induced euphoria, withdrawal dysphoria and cocaine- conditioned craving, (2) to investigate differences in regional brain activation by cocaine in nondependent versus dependent users. In order to take full advantage of the strengths of fMRI, one aspect of the program involves technical development of this tool, optimizing its ability to image cortical and subcortical structures hypothesized to play key roles in the human brain reward circuitry. Animal models are used in the program because they are necessary to interpret the biological significance of human fMRI data and to relate it well validated molecular models of cocaine-induced neural activation.