ALUMINUM ABSORPTION--EFFECT OF CALCIUM CITRATE ON ALUMINUM CONTAINING ANTACIDS

铝吸收--柠檬酸钙对含铝抗酸剂的影响

• 批准号: 3742808
• 负责人: KHASHAYAR SAKHAEE
• 金额: --
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3742808
• 关键词: aluminum; antacids; calcium; citrates; combination chemotherapy; drug interactions; gastrointestinal drug absorption; human subject; malabsorption; metal complex

The objective of this study is to determine whether calcium citrate given together with aluminum-containing antacids would enhance the intestinal absorption of aluminum, and if so, whether this enhancing effect could be over come by giving calcium citrate separately from aluminum-containing antacids. The proposal will test the hypothesis that the concurrent administration of the above two salts would result in enhanced aluminum absorption from the formation of absorbable aluminum-citrate complex.

本研究的目的是确定是否给予柠檬酸钙 与含铝抗酸剂一起使用可增强肠道 铝的吸收，如果是的话，这种增强作用是否可以 通过单独给予柠檬酸钙来克服 含铝抗酸剂。 该提案将检验以下假设： 同时服用上述两种盐会导致 形成可吸收的增强铝吸收 柠檬酸铝络合物。