ALUMINUM ABSORPTION--EFFECT OF CALCIUM CITRATE ON ALUMINUM CONTAINING ANTACIDS

铝吸收--柠檬酸钙对含铝抗酸剂的影响

• 批准号: 6117524
• 负责人: KHASHAYAR SAKHAEE
• 金额: $ 3.12万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6117524
• 关键词: aluminum; antacids; calcium; citrates; clinical research; drug interactions; gastrointestinal drug absorption; human subject; nutrition related tag

The objective of this study is to determine whether calcium citrate given together with aluminum-containing antacids would enhance the intestinal absorption of aluminum, and if so, whether this enhancing effect could be oversome by giving calcium citrate separately from aluminum-containing antacids. The proposal will test the hypothesis that the concurrent administration of above two salts would resulta in enhanced aluminum absorption from the formation of absorbable aluminum- citrate complex.

这项研究的目的是确定柠檬酸钙是否 与含铝抗酸剂一起服用会增强 肠道对铝的吸收，如果是这样的话，这是否会增强 如果将柠檬酸钙与其他药物分开给药，效果可能会过度 含铝的抗酸剂。这项提议将检验这一假设 同时服用上述两种盐将导致 从可吸收铝的形成中增强铝的吸收- 柠檬酸盐复合体。