Coordination of withdrawal from the cell cycle by transcriptional repression

点击翻译按钮获取中文摘要

Cancer is characterised by changes in several fundamental cellular processes including the failure of the cancer cells to stop growing in response to the body's normal stop signals.. When cells normally stop growing there is profound changes in the activity of many genes. This proposal aims to investigate how these changes in gene activity are brought about. We propose that a recently discovered family of genes called SWI-SNF work with two other families of genes (the Mad-family and Rb-family) to bring about the cessation of cell growth. If our proposal is proven it will open new avenues to evaluate the growth properties of human cancers and may lead to novel strategies to inhibit cell growth.