RNA Polymerase I: A novel target in the treatment of MYC driven malignancies

核糖体的合成是细胞蛋白质合成的机械，在癌症过程中受到失调，导致假设它可能在癌症过程中起到致病作用。这项应用将在一种名为E�-myc的小鼠遗传模型中使用新的抑制剂或核糖体生物发生来验证这一假设，该模型忠实地复制了人类B细胞淋巴瘤。这些研究将揭示恶性转化的新机制，并确定治疗人类癌症的新疗法。

Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be causative in the malignant process. This application will test this hypothesis using novel inhibitors or ribosome biogenesis in a mouse genetic model termed E�-MYC that faithfully that replicates human B-cell lymphoma. These studies will uncover novel mechanisms in malignant transformation and identify new therapeutics in the treatment of human cancer.