RNA Polymerase I: A novel target in the treatment of MYC driven malignancies
RNA Polymerase I: A novel target in the treatment of MYC driven malignancies
批准号:
nhmrc : 1003270
负责人:
Prof Grant Mcarthur
金额:
$40.41万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be causative in the malignant process. This application will test this hypothesis using novel inhibitors or ribosome biogenesis in a mouse genetic model termed E�-MYC that faithfully that replicates human B-cell lymphoma. These studies will uncover novel mechanisms in malignant transformation and identify new therapeutics in the treatment of human cancer.
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依托单位:
海外基金