Inhibition of CHK1 kinase for cancer therapy

抑制 CHK1 激酶用于癌症治疗

• 批准号: nhmrc : 509298
• 负责人: Prof Grant Mcarthur
• 金额: $ 26.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-chk1-kinase-cancer-therapy/77095
• 关键词: Inhibition; CHK1; kinase; cancer; therapy

The use of chemotherapy for the treatment of cancer has improved outcomes in many types of cancer. Recent reserach has uncovered how and why cancer cells respond to chemotherapy. This reserach proposal will use this knowledge to evaluate a new approach to cancer treatment by targeting a process called cell cycle checkpoints. Specifically this proposal will evaluate the difference between normal cells and cancer cells and use imaging to examine response to these new treatments.

使用化疗来治疗癌症已经改善了许多类型癌症的结果。最近的研究揭示了癌细胞如何以及为何对化疗产生反应。该研究提案将利用这些知识通过针对称为细胞周期检查点的过程来评估癌症治疗的新方法。具体来说，该提案将评估正常细胞和癌细胞之间的差异，并使用成像技术来检查对这些新疗法的反应。