Targeting MYC-driven cancers by inhibition of the mTOR pathway

通过抑制 mTOR 通路靶向 MYC 驱动的癌症

• 批准号: nhmrc : 566876
• 负责人: Prof Grant Mcarthur
• 金额: $ 36.54万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-myc-driven-mtor-pathway/99562
• 关键词: Targeting; MYC; driven; cancers; inhibition

This proposal will evaluate a new strategy for treating cancers associated with the cancer causing gene MYC. Globally there are more than 1 million cases of MYC-associated cancers diagnosed per year. Based on encouraging early results we will test if turning off the proteins associated with mTOR will be an effective strategy for treating MYC cancers using state-of-the-art cancer models and investigate why these cancers respond.

该提案将评估一种治疗与致癌基因MYC相关的癌症的新策略。全球每年诊断出超过100万例MYC相关癌症病例。基于令人鼓舞的早期结果，我们将测试关闭与mTOR相关的蛋白质是否是使用最先进的癌症模型治疗MYC癌症的有效策略，并研究这些癌症响应的原因。