Targeting Oncogene Addiction

针对癌基因成瘾

• 批准号: nhmrc : 1002654
• 负责人: Prof Grant Mcarthur
• 金额: $ 36.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Practitioner Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-oncogene-addiction/108841
• 关键词: Targeting; Oncogene; Addiction

Major advances in cancer treatment has been made by identifying gene mutations in cancers to which the cancer is “addicted”, such that turning off the effects of the mutations leads to death of the cancer cells. Grant McArthur has been successful in applying this principle to rare types of sarcoma bringing his work to routine clinical practice globally. In this application he will investigate targeting the BRAF, KIT and MYC genes focusing on melanoma, a major cancer problem in Australia.

在癌症治疗方面取得的重大进展是，确定了癌症“上瘾”的癌症的基因突变，从而关闭突变的影响，导致癌细胞死亡。Grant McArthur已经成功地将这一原理应用于罕见类型的肉瘤，将他的工作带到全球的常规临床实践中。在这个申请中，他将研究针对黑色素瘤的BRAF、KIT和MYC基因，这是澳大利亚的一个主要癌症问题。