BIOMEDICAL IMAGE PROCESSING

生物医学图像处理

• 批准号: 3752806
• 负责人: B L TRUS
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752806
• 关键词: bioengineering /biomedical engineering; biosensor device; brain imaging /visualization /scanning; brain metabolism; clinical biomedical equipment; computed axial tomography; computer program /software; computer system design /evaluation; digital imaging; head movements; image processing; mathematical model; method development; neuroanatomy; nuclear medicine; personal computers; positron emission tomography

The superposition and registration of differing tomographic views is a difficult problem for investigators attempting to correlate brain form (structure), derived from x-ray computed tomography (CT) images, with brain function (metabolism), revealed by nuclear medicine positron emission tomography (PET) images. For this reason, an attempt is being made to develop techniques for the accurate correlation of CT structural data with PET metabolic information, in order to enhance our understanding of the processes underlying the generation of PET images. Our approach has three stages: firstly, practical methods must he discovered for the accurate and reproducible placement of the head within a tomographic scanner's aperture; secondly, techniques for monitoring head position during the image acquisition process must be developed to correct for head movement before the image is generated; thirdly, simplified algorithms must be found for scaling and registering digitized images from different scanners on a digital display subsystem. Precise orientation of the subject's skull within the scanner's aperture is monitored and recorded with a PC-based Polhemus position/orientation measurement subsystem, allowing simultaneous use of two independent sensors. The development of two inexpensive custom-molded oral appliances allows the Polhemus subsystem's sensor to be fixed to the subject's skull. A novel targeting algorithm was derived to provide to the system operator visual cues related to head position within a scanner's imaging volume. Two-sensor software was completed, and extensive evaluation has begun prior to its experimental use with test subjects. An additional position/orientation measurement subsystem has been obtained and evaluated for linearity and for sensitivity to nearby metallic objects, a problem common to an electromagnetic-based tracking systems. This device's utilization of quasi-static fields was designed to increase its immunity to close proximity of certain types of metal. Although performance of this new position measurement system was good, it did not outperform the Polhemus system in the presence of PET scanners.

不同断层图像的叠加和配准是一种 试图关联大脑形态的研究人员面临的难题 (结构)，来自X射线计算机断层扫描(CT)图像，具有 核医学正电子揭示的脑功能(代谢) 发射断层扫描(PET)图像。 出于这个原因，人们正在尝试开发用于 CT结构数据与PET代谢信息的准确关联， 为了加深我们对潜在过程的了解 生成PET图像。 我们的方法有三个阶段：第一，实用的方法必须 被发现是为了准确和可重复地将头部放置在 断层扫描仪的孔径；第二，监测头部的技术 必须对图像采集过程中的位置进行开发以纠正 用于生成图像之前的头部移动；第三，简化 必须找到缩放和配准数字化图像的算法 数字显示子系统上的不同扫描仪。 受试者头骨在扫描仪孔径内的精确定位 使用基于PC的Polhemus位置/方向进行监控和记录 测量子系统，允许同时使用两个独立的 传感器。两种廉价定制口腔矫治器的研制 允许波尔希默斯子系统的传感器固定在受试者的头骨上。 推导了一种新的目标定位算法，为系统操作员提供了一种新的目标定位算法 与扫描仪成像体积内的头部位置相关的视觉提示。 完成了两个传感器的软件，并开始了广泛的评估 在对测试对象进行实验使用之前。 获得了一个附加的位置/方位测量子系统 并评估了线性度和对附近金属的敏感性 目标，这是基于电磁的跟踪系统常见的问题。 该装置对准静态场的利用旨在提高 它对某些类型的金属的近距离免疫。虽然 这个新的位置测量系统的性能是好的，它不是 在有PET扫描仪的情况下，性能优于Polhemus系统。