ELECTRICAL AND CHEMICAL OSCILLATIONS IN COUPLED CELL SYSTEMS

耦合电池系统中的电振荡和化学振荡

• 批准号: 3753922
• 负责人: A SHERMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3753922
• 关键词: Langerhans' cell; biophysics; cell cell interaction; cell membrane; electrophysiology; insulin; intracellular; mathematical model; membrane activity; membrane channels; membrane model; membrane potentials; model design /development; neurons; pancreatic islet function; pancreatic islets; secretion

We use mathematical models to study the mechanisms of oscillatory electrical activity arising from ion channels in cell membranes and modulated by intracellular chemical processes. We are interested in both the behavior of single cells and the ways in which cells communicate and modify each other's behavior Our main application has been to the biophysical basis of insulin secretion in pancreatic beta-cells. We have examined bursting oscillations in membrane potential and the role of electrical coupling between cells in the islet of Langerhans. Long term goals are to understand how the membrane dynamics interact with intracellular events to regulate secretion and to generalize to other secretory cells and neurons. Our primary tool is the numerical solution of ordinary and partial differential equations. We use analytical, geometrical, graphical, and numerical techniques from the mathematical theory of dynamical systems to help construct and interpret the models. Perturbation techniques are used to get analytical results in special cases. We study both detailed biophysical models and simplified models which are more amenable to analysis. Such an approach aids the isolation of the essential or minimal mechanisms underlying phenomena, the search for general principles, and the application of concepts and analogies from other fields. We see a role for our group as intermediaries between the mathematical and biological disciplines. This includes disseminating the insights of mathematical work to biologists in accessible language and alerting mathematicians and other theoreticians to new and challenging problems arising from biological issues.

我们用数学模型来研究振荡的机制。 细胞膜中离子通道产生的电活动和 受细胞内化学过程的调节。我们对这两个都感兴趣 单个细胞的行为以及细胞之间的通信和 修改彼此的行为 我们的主要应用是胰岛素的生物物理基础。 胰岛β细胞的分泌。我们已经检查了爆裂 膜电位的振荡与电耦合的作用 在朗格汉斯胰岛的细胞之间。长期目标是 了解膜动力学如何与细胞内事件相互作用 调节分泌，并推广到其他分泌细胞和 神经元。 我们的主要工具是常解和偏解的数值解 微分方程式。我们使用分析、几何、图形和 动力系统数学理论中的数值技术 帮助构建和解释模型。微扰技术有 用于在特殊情况下获得分析结果。 我们研究了详细的生物物理模型和简化的模型，它们是 更易于分析。这样的方法有助于隔离 现象背后的基本或最小的机制，对 一般原理，以及概念和类比的应用 其他字段。 我们认为，我们的团队将扮演一个中介角色，在 和生物学科。这包括传播对 以通俗易懂的语言和警报向生物学家提供数学工作 数学家和其他理论家对新的和具有挑战性的问题的研究 由生物问题引起的。