ELECTRICAL AND CHEMICAL OSCILLATIONS IN COUPLED CELL SYSTEMS

耦合电池系统中的电振荡和化学振荡

• 批准号: 3776033
• 负责人: A SHERMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3776033
• 关键词: Langerhans' cell; biophysics; cell cell interaction; electrophysiology; insulin; intracellular; mathematical model; membrane activity; membrane channels; membrane model; membrane potentials; model design /development; neurons; pancreatic islet function; pancreatic islets; secretion

We use mathematical models to study the mechanisms oscillatory electrical activity arising from ion channels in cell membranes and modulated by intracellular chemical processes. We are interested both the behavior of single cells and the ways in which cells communicate and modify each other's behavior. Our main application has been to the biophysical basis of insulin secretion in pancreatic beta-cells. We have examined bursting oscillations in membrane potential and the role of electrical coupling between cells in the islet of Langerhans. Long term goals are to understand how the membrane dynamics interact with intracellular events to regulate secretion and to generalize to other secretory cells and neurons. Our primary tool is the numerical solution of ordinary and partial differential equations. We use analytical, geometrical, graphical, and numerical techniques from the mathematical theory of dynamical systems to help construct and interpret the models. Perturbation techniques are used to get analytical results in special cases. We study both detailed biophysical models and simplified models which are more amenable to analysis. Such an approach aids the isolation of the essential or minimal mechanisms underlying phenomena, the search for general principles, and the application of concepts and analogies from other fields. We see a role for our group as intermediaries between the mathematical and biological disciplines. This includes disseminating the insights of mathematical work to biologists in accessible language and alerting mathematicians and other theoreticians to new and challenging problems arising from biological issues.

我们使用数学模型来研究振荡电的机制， 由细胞膜中的离子通道产生的活性， 细胞内化学过程 我们感兴趣的是 以及细胞之间的交流和改变 别人的行为。 我们的主要应用是胰岛素的生物物理基础 胰腺β细胞分泌。 我们已经研究了爆裂 膜电位振荡和电耦合的作用 在胰岛细胞之间。 长期目标是 了解膜动力学如何与细胞内事件相互作用 调节分泌并推广到其他分泌细胞， 神经元 我们的主要工具是数值解的普通和部分 微分方程 我们使用分析的，几何的，图形的， 动力系统数学理论中的数值技术 来帮助构建和解释模型。 扰动技术是 用于在特殊情况下得到分析结果。 我们研究了详细的生物物理模型和简化模型， 更容易分析。 这种方法有助于隔离 基本或最低限度的机制的现象，寻找 一般原则，以及概念和类比的应用， 其他领域 我们认为我们的团队的作用是作为数学之间的中介， 和生物学科。 这包括传播以下方面的见解： 以易于理解的语言和警觉向生物学家提供数学工作 数学家和其他理论家对新的和具有挑战性的问题 由生物学问题引起的。