EVALUATIONS OF GENETIC TOXICITY TEST RESULTS

遗传毒性试验结果评价

• 批准号: 3755360
• 负责人: E ZEIGER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3755360
• 关键词: DNA damage; Rodentias; carcinogen testing; chemical carcinogen; chemical carcinogenesis; chemical information system; chemical structure function; chromosome aberrations; genetic crossing over; mutagen testing; mutagens; toxicant screening

A database of NTP short-term genetic toxicity test results and the results from carcinogenesis tests has been created. This database allows the evaluation of each short-term assay with respect to its ability to predict carcinogenesis or other short-term assay results. It also permits studies of the individual assays with respect to inter- and intra-laboratory reproducibility. Examination of test predictivity as a function of the potency of the short-term test (STT) and carcinogenicity test is continuing. The chemicals being evaluated comprise the 114-chemical dataset used previously to correlate qualitative STT results with carcinogenicity results. The short-term genetic toxicity results are being integrated with other toxicity and biochemical parameters of these chemicals in an attempt to improve the prediction of carcinogenicity and other toxic effects. A number of potency measures have been proposed for the Salmonella and carcinogenesis tests, but there are no commonly-accepted measures of potency for the other STTs, such as in vitro chromosome aberrations, in vitro SCE, or the mouse lymphoma test. The measurements used for Salmonella are being redefined to fit the data from the mammalian cell assays, and are being used to evaluate the relationships of the in vivo tests with the carcinogenic potencies for the same chemicals.

NTP短期遗传毒性试验结果数据库和 致癌性测试的结果已经产生。 此数据库 允许评价每个短期试验， 预测致癌作用或其他短期测定结果的能力。它 还允许研究个体测定， 实验室内重现性。 检验预测性作为 短期试验（STT）效价和致癌性的功能 测试仍在继续。 正在评估的化学品包括 114-先前用于关联定性STT结果的化学数据集 致癌性结果。短期遗传毒性结果为 与其他毒性和生化参数相结合， 化学品，试图改善致癌性的预测， 其他毒性作用。 针对沙门氏菌提出了许多效力措施 和致癌性测试，但没有普遍接受的措施， 对其他STT的效力，如体外染色体畸变， 体外SCE或小鼠淋巴瘤试验。 测量用于 沙门氏菌正在重新定义，以适应哺乳动物细胞的数据， 分析，并被用来评估体内的关系， 测试相同化学物质的致癌效力。