METABOLISM OF XENOBIOTICS TO MUTAGENS USING NON-HEPATIC MICROSOMAL ENZYME SYSTEMS

使用非肝微粒体酶系统将异生物质代谢为诱变剂

• 批准号: 4693174
• 负责人: E ZEIGER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693174
• 关键词: Salmonella; benzopyrenes; biotransformation; carbopolycyclic compound; cyclic amine; diol; epoxides; liver; liver metabolism; lung; microsomes; mutagen testing; mutagens; nitrosamines; prostaglandin endoperoxide synthase; prostate; quinoline; testis; toxin metabolism; unspecific monooxygenase

Xenobiotic chemicals can be metabolized by orans and tissues other than the liver. Additionally, the prostaglandin endoperoxide synthetase (PES) system is found in a number of organs and is not dependent on cytochrome P-450. The metabolism of aromatic amines, imidazoquinolines and other chemicals to mutagens in Salmonella tester strains was studied using PES. Specifically, the aromatic amines and imidazoquinolines being studied are those formed in beef during cooking, or from amino acids undergoing pyrolysis. All these chemicals are mutagenic following metabolism by liver, and other organ P-450-dependent mixed function oxidases.

异源生物化学物质可以被猩猩和组织代谢，而不是 肝脏。此外，前列腺素内过氧化合成酶(PES) 该系统存在于许多器官中，不依赖于细胞色素 P-450。芳香胺、咪唑喹啉等的代谢 用PES法研究了化学物质对沙门氏菌检测菌株的致突变作用。 具体地说，正在研究的芳香胺和咪唑喹啉是 在牛肉烹调过程中形成的那些物质，或者是从经过 热解。所有这些化学物质在新陈代谢后都会发生突变 肝脏等器官依赖P-450的混合功能氧化酶。