EVALUATION OF SALMONELLA MUTAGENICITY TESTING RESULTS

沙门氏菌致突变性检测结果的评价

• 批准号: 3965188
• 负责人: E ZEIGER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965188
• 关键词: Salmonella typhimurium; chemical carcinogenesis; chromosome aberrations; chromosome disorders; genetic strain; mutagen testing; statistics /biometry; toxicant screening

The database from the testing of approximately 1200 chemicals for mutagenicity in Salmonella is being analyzed. Approximately 250 of these chemicals have also been tested for carcinogenicity by the NCI/NTP. There are also a large number of chemicals that have also been tested for their ability to mutate mouse lymphoma (L5178Y) cells, or produce chromosome damage in cultured Chinese hamster ovary (CHO) cells. The correlations between Salmonella mutagenicity and carcinogenicity are being analyzed, as well as the correlations between Salmonella mutagenicity and the responses in mammalian cells. A mutagenic response in Salmonella is highly predictive of carcinogenicity, whereas a negative response is not predictive of noncarcinogenicity. The correlation achieved between mutagenicity and carcinogenicity is highly dependent on the class of chemical examined. The other in vitro test systems, when used in concert with, or subsequent to Salmonella, do not appear to significantly enhance the predictivity.

该数据库来自对大约1200种化学品的测试 沙门氏菌的致突变性正在分析中。其中大约有250个 NCI/NTP还对化学品的致癌性进行了测试。那里 也有大量的化学物质也进行了测试 突变小鼠淋巴瘤(L5178Y)细胞或产生染色体的能力 中国仓鼠卵巢(CHO)细胞的损伤。它们之间的关联 沙门氏菌的致突变性和致癌性之间的关系正在分析中，因为 沙门氏菌致突变性与免疫应答的相关性 在哺乳动物细胞中。沙门氏菌的一种突变反应是高度 预测致癌性，而阴性反应不是 非致癌性的预测。两者之间的相关性 致突变性和致癌性高度依赖于 检查了化学物质。其他体外测试系统，当配合使用时 在沙门氏菌感染后或之后，似乎没有显著增强 可预见性。