EVALUATIONS OF GENETIC TOXICITY TEST RESULTS

遗传毒性试验结果评价

• 批准号: 3941501
• 负责人: E ZEIGER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941501
• 关键词: Salmonella; azo compounds; chemical carcinogen; chemical carcinogenesis; chlorohydrocarbon; chromosome aberrations; mutagen testing; phthalates; toxicant screening

A database of results from the Salmonella, chromosome aberration, and sister chromatid exchange assays has been created using chemicals tested for carcinogenicity by the NCI ad the NTP. This database allows the evaluation of each short-term assay with respect to its ability to predict carcinogenesis or the other short- term assays results. it was shown that no assay can detect all carcinogens. In this database, a positive result in Salmonella is the best predictor of carcinogencity in rodents. In fact, its predictivity is equivalent to the predictivity of rat carcinogenesis from mouse carcinogenesis, and vice versa. No battery of assays composed of the assays mentioned above was superior to Salmonella, alone, for predicting carcinogenicity. Also, none of the assays were complementary to each other. The Salmonella assay differed markedly in its responses to chemicals of different classes; it was relatively insensitive to chlorinated hydrocarbons and phthalate esters, but highly sensitive to nitro and azo compounds. These analyses will lead to an assessment of the ability of short-term genetic toxicity assays to predict rodent carcinogenicity, and to the design of strategies for the deployment of short-term tests.

沙门氏菌的结果数据库，染色体 已经建立了姐妹染色单体交换分析 使用经NCI和NTP检测致癌的化学品。 该数据库允许对每个短期化验结果进行评估 关于它预测癌症发生的能力或其他短期的- 定期化验结果。结果表明，没有一种检测方法可以检测到所有的 致癌物质。在这个数据库中，沙门氏菌的阳性结果是 啮齿动物致癌性的最佳预测因子。事实上，它的 可预测性等同于大鼠致癌的可预测性 小鼠致癌，反之亦然。没有一组化验 由上述检测方法组成的比色法优于 沙门氏菌，单独用于预测致癌性。此外，没有一个 这些检测方法是相辅相成的。沙门氏菌 试剂盒对不同化学物质的反应有显著差异 类；对氯代烃相对不敏感 和邻苯二甲酸酯，但对硝基和偶氮高度敏感 化合物。这些分析将导致对 短期遗传毒性试验预测啮齿动物的能力 致癌性，以及为 部署短期测试。