AXONAL SPROUTING AND ITS RELATION TO A CENTRAL PAIN STATE

轴突萌芽及其与中枢疼痛状态的关系

• 批准号: 3760480
• 负责人: RICHARD E. COGGESHALL
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3760480
• 关键词: axon; calcitonin gene related peptide; dendrites; denervation; dopamine beta monooxygenase; dorsal horn; electron microscopy; enkephalins; gamma aminobutyrate; immunocytochemistry; laboratory rat; longitudinal animal study; microscopy; nerve endings; nervous system regeneration; neural growth associated protein; neuroanatomy; neuronal guidance; neurons; pain; spinal cord surgery; substance P; synapses; synaptogenesis; thalamus

The goal of this project is to determine how the architecture of the spinal cord changes after chronic sensory denervation, and to correlate these changes with autonomy, which is generally accepted as a model of a central pain state, and with changes in the synaptic patterns on spinothalamic cells. The hypotheses being tested are that synaptic numbers in the dorsal horn will drop after rhizotomy, that at some point after this synaptic numbers will rise (sprouting) perhaps back to normal levels, that this sprouting will be manifest by an increase in synaptic numbers, a change in the synaptic patterns on spinothalamic cells and a change in the architecture of the spinal cord, and that the onset of sprouting will be correlated with the appearance of autonomy. If these hypotheses turn out to be correct, then experimental procedures can be developed that hopefully will modify the sprouting and the appearance of autonomy. Such data should impact on the dysesthesias that often plague human victims of sensory denervation.

该项目的目标是确定脊柱的结构如何 慢性感觉去神经支配后的脊髓变化，并将这些变化关联起来 随着自治的变化而变化，这被普遍认为是中央集权的模式 疼痛状态以及脊髓丘脑突触模式的变化 细胞。 正在测试的假设是背侧的突触数量 根切断术后角会掉落，在突触后的某个时刻 数量会上升（发芽），也许会回到正常水平，这 发芽将通过突触数量的增加、 脊髓丘脑细胞上的突触模式和变化 脊髓的结构，并且发芽的开始将是 与自主性的表现相关。 如果这些假设成立 是正确的，那么可以开发实验程序，希望 将改变发芽和自主的外观。 此类数据应 对经常困扰人类感官受害者的感觉迟钝的影响 去神经支配。