AXONAL SPROUTING AND ITS RELATION TO A CENTRAL PAIN STATE

该项目的目标是确定脊柱的架构如何 慢性感觉神经丧失后脊髓的变化及其相互关系 随着自主权的变化，这被普遍认为是中央的典范 疼痛状态，以及脊髓丘脑突触模式的变化 细胞。正在测试的假设是背部的突触数量 在切断神经根后，角会掉落，在突触之后的某个时间点 数字将会上升(萌芽)，可能会回到正常水平，这 发芽将表现为突触数量的增加，即 脊髓丘脑细胞上的突触模式和 脊髓的结构，发芽的开始将是 与自主性的出现相关。如果这些假设成为事实 如果是正确的，那么就有希望开发出实验程序 会修饰萌芽和自主性的外观。这样的数据应该 对经常折磨人类感官受害者的感觉障碍的影响 神经丧失。

The goal of this project is to determine how the architecture of the spinal cord changes after chronic sensory denervation, and to correlate these changes with autonomy, which is generally accepted as a model of a central pain state, and with changes in the synaptic patterns on spinothalamic cells. The hypotheses being tested are that synaptic numbers in the dorsal horn will drop after rhizotomy, that at some point after this synaptic numbers will rise (sprouting) perhaps back to normal levels, that this sprouting will be manifest by an increase in synaptic numbers, a change in the synaptic patterns on spinothalamic cells and a change in the architecture of the spinal cord, and that the onset of sprouting will be correlated with the appearance of autonomy. If these hypotheses turn out to be correct, then experimental procedures can be developed that hopefully will modify the sprouting and the appearance of autonomy. Such data should impact on the dysesthesias that often plague human victims of sensory denervation.