AXONAL SPROUTING AND ITS RELATION TO A CENTRAL PAIN STATE

轴突萌芽及其与中枢疼痛状态的关系

• 批准号: 3846485
• 负责人: RICHARD E. COGGESHALL
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3846485
• 关键词: axon; calcitonin gene related peptide; dendrites; denervation; dopamine beta monooxygenase; dorsal column; electron microscopy; enkephalins; gamma aminobutyrate; immunocytochemistry; laboratory rat; longitudinal animal study; microscopy; nerve endings; nervous system regeneration; neural growth associated protein; neuroanatomy; neuronal guidance; neurons; pain; spinal cord; spinal cord surgery; substance P; synapses; synaptogenesis; thalamus

The goal of this project is to determine how the architecture of the spinal cord changes after chronic sensory denervation, and to correlate these changes with autonomy, which is generally accepted as a model of a central pain state, and with changes in the synaptic patterns on spinothalamic cells. The hypotheses being tested are that synaptic numbers in the dorsal horn will drop after rhizotomy, that at some point after this synaptic numbers will rise (sprouting) perhaps back to normal levels, that this sprouting will be manifest by an increase in synaptic numbers, a change in the synaptic patterns on spinothalamic cells and a change in the architecture of the spinal cord, and that the onset of sprouting will be correlated with the appearance of autonomy. If these hypotheses turn out to be correct, then experimental procedures can be developed that hopefully will modify the sprouting and the appearance of autonomy. Such data should impact on the dysesthesias that often plague human victims of sensory denervation.

该项目的目标是确定脊柱的结构如何 慢性感觉失神经支配后脊髓的变化，并将这些变化与 随着自治而变化，这被普遍认为是中央政府的一种模式。 疼痛状态，并与脊髓丘脑突触模式的变化 细胞 正在测试的假设是，在背侧的突触数量， 角在神经根切断术后会脱落，在这个突触后的某个时刻， 数字将上升（发芽）也许回到正常水平，这是 发芽将表现为突触数量的增加， 脊髓丘脑细胞上的突触模式和 脊髓的结构，发芽的开始将是 与自主性的出现有关。 如果这些假设被证明 正确的话，就可以开发实验程序， 将改变自主性的萌芽和外观。 这种数据应 对感觉迟钝的影响， 去神经