THE ROLE OF THE MOLECULES INTERACTING WITH FC EPSILON RI IN SIGNAL TRANSDUCTION

与 FC EPSILON RI 相互作用的分子在信号转导中的作用

• 批准号: 3768898
• 负责人: J P KINET
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3768898
• 关键词: antibody receptor; biological signal transduction; immunoglobulin E; molecular cloning; monoclonal antibody; phosphomonoesterases; protein kinase; receptor binding

We found recently that the FcepsilonRI receptor becomes associated with other molecules upon receptor engagement. We are attempting to characterize these molecules and to raise new monoclonal antibodies against them. We are also attempting to clone these molecules with various methods. Finally we are trying to better define the set of kinases and phosphatases involved in receptor signalling and to analyze their relative importance.

我们最近发现，FcepsilonRI受体与 其他分子对受体结合的影响。 我们正试图 鉴定这些分子并产生新的单克隆抗体 反对他们 我们还试图克隆这些分子， 各种方法。 最后，我们试图更好地定义 参与受体信号传导的激酶和磷酸酶并进行分析 其相对重要性。