GENE SPECIFIC DNA REPAIR

基因特异性 DNA 修复

• 批准号: 3767865
• 负责人: V A BOHR
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767865
• 关键词: DNA damage; DNA repair; chromosome translocation; gene rearrangement; genome; neoplasm /cancer genetics; neoplastic cell

We are studying the molecular biochemistry of gene specific DNA repair with a view to clarify which gene products are involved and how these processes are regulated as compared to the DNA repair processes in the general, overall bulk of the genome. There are distinct differences in the efficiency of gene- and strand specific DNA repair dependent upon the type of DNA damage, and it is possible that the local degree of chromosomal distortion after DNA damage is the important element in determining the repair response chosen by the cell. We are suggesting that proficient DNA repair is necessary to secure genomic stability, and we find that certain regions of the genome that undergo translocation or rearrangements in the tumor cells are poorly repaired in cells that are susceptible to cancer.

我们正在研究基因特异性DNA修复的分子生物化学 为了阐明涉及哪些基因产物以及这些基因产物是如何产生的， 与DNA修复过程相比， 基因组的整体。 有明显的区别 基因和链特异性DNA修复依赖于 DNA损伤的类型，并且有可能局部程度 DNA损伤后的染色体畸变是 确定由所述细胞选择的所述修复响应。 我们建议 熟练的DNA修复是确保基因组稳定性所必需的， 我们发现基因组的某些区域 肿瘤细胞中的易位或重排修复不良 在易患癌症的细胞中。